MOUSE ANTI HUMAN CD275

GWB-B2D448

IgG1

Phosphate buffered saline pH7. 4

CD275 - L cells

Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions as well as in modulating the secondary immune response by co-stimulating memory T-cell function By similarity. Subcellular locationMembrane; Single-pass type I membrane protein By similarity. Tissue specificityIsoform 1 is widely expressed (brain heart kidney liver lung pancreas placenta skeletal muscle bone marrow colon ovary prostate testis lymph nodes leukocytes spleen thymus and tonsil) while isoform 2 is detected only in lymph nodes leukocytes and spleen. Expressed on activated monocytes and dendritic cells. Ref. 7Induction: Constitutive expression is further enhanced by treatment with TNF-alpha in peripheral blood B-cells and monocytes while it is decreased in dendritic cells. Sequence similaritiesBelongs to the immunoglobulin superfamily. BTN/MOG family. Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Contains 1 Ig-like V-type (immunoglobulin-like) domain. Sequence cautionThe sequence BAA31628. 1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence BAA31628. 1 differs from that shown. Reason: The sequence differs from that shown in position 300 onward for unknown reason. 1. Hiura H. et al. (2010) A tripartite paternally methylated region within the Gpr1-Zdbf2 imprinted domain on mouse chromosome 1 identified by meDIP-on-chip. Nucleic Acids Res. Apr 29. [Epub ahead of print]