MOUSE ANTI HUMAN DECTIN-1

DECTIN-1

Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant

Recognises human Dectin-1 also known as beta-glucan receptor (& #223; GR) a C-type lectin domain family member. It is a major pathogen pattern-recognition receptor that binds beta-glucans glucose polymers that form cell-wall components or exopolymers of yeasts fungi and some bacteria. Beta-glucans have also been used experimentally and therapeutically as immunomodulators that enhance resistance to bacterial yeast viral and protozoan infections as well as tumor formation. Dectin-1 also acts as a co-stimulatory molecule on T-cells to induce their proliferation and is necessary for the TLR2-mediated inflammatory response. It is highly expressed on peripheral blood leukocytes and dendritic cells. Human Dectin-1 has two major (& #223; GR-A and & #223; GR-B) and several minor isoforms. & #223; GR-A and & #223; GR-B differs by the presence and absence respectively of a stalk region. Clone BD6 recognises & #223; GR-A only. Recommended Negative Controls: MOUSE IgG2b NEGATIVE CONTROLRecommended Secondary Antibodies: Rabbit Anti Mouse IgGGoat Anti Mouse IgGRabbit Anti Mouse IgGGoat Anti Mouse IgGGoat Anti Mouse IgG (H/L)Goat Anti Mouse IgGGoat Anti Mouse IgG IgA IgMRabbit Anti Mouse IgGHuCAL Anti Mouse IgG2bGoat Anti Mouse IgG (Fc)Sheep Anti Mouse IgG (H/L) [1] \" Mapping characterization and expression analysis of the SM-20 human homologue C1orf12 and identification of a novel related gene SCAND2. \" Dupuy D. Aubert I. Duperat V. G. Petit J. Taine L. Stef M. Bloch B. Arveiler B. Genomics 69:348-354(2000) [PubMed: 11056053] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1) TISSUE SPECIFICITY. [2] \" Characterization and comparative analysis of the EGLN gene family. \" Taylor M. S. Gene 275:125-132(2001) [PubMed: 11574160] [Abstract]Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 1). [3] \" The full-ORF clone resource of the German cDNA consortium. \" Bechtel S. Rosenfelder H. Duda A. 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[7] \" C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. \" Epstein A. C. R. Gleadle J. M. McNeill L. A. Hewitson K. S. O\' Rourke J. Mole D. R. Mukherji M. Metzen E. Wilson M. I. Dhanda A. Tian Y. M. Masson N. Hamilton D. L. Jaakkola P. Barstead R. Hodgkin J. Maxwell P. H. Pugh C. W. Schofield C. J. Ratcliffe P. J. Cell 107:43-54(2001) [PubMed: 11595184] [Abstract]Cited for: FUNCTION. [8] \" Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor. \" Ivan M. Haberberger T. Gervasi D. C. Michelson K. S. Guenzler V. Kondo K. Yang H. Sorokina I. Conaway R. C. Conaway J. W. Kaelin W. G. Jr. Proc. Natl. Acad. Sci. U. S. A. 99:13459-13464(2002) [PubMed: 12351678] [Abstract]Cited for: FUNCTION. [9] \" Overexpression of PH-4 a novel putative proline 4-hydroxylase modulates activity of hypoxia-inducible transcription factors. \" Oehme F. Ellinghaus P. Kolkhof P. Smith T. J. Ramakrishnan S. Huetter J. Schramm M. Flamme I. Biochem. Biophys. Res. Commun. 296:343-349(2002) [PubMed: 12163023] [Abstract]Cited for: TISSUE SPECIFICITY. [10] \" Differential regulation of HIF-1alpha prolyl-4-hydroxylase genes by hypoxia in human cardiovascular cells. \" Cioffi C. L. Qin Liu X. Kosinski P. A. Garay M. Bowen B. R. Biochem. Biophys. Res. Commun. 303:947-953(2003) [PubMed: 12670503] [Abstract]Cited for: TISSUE SPECIFICITY ENZYME REGULATION.