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MOUSE ANTI HUMAN DECTIN-1:RPE

MOUSE ANTI HUMAN DECTIN-1:RPE

ArtNr	20-783-315465
Hersteller	GENWAY
Menge	25 TESTS
Kategorie	Oncology Neuroscience Neural Lineage Markers Antibodies Primary Antibodies By Organ Uterine, Ovarian & Cervical Cancer
Typ	Antibody
Specific against	Human (Homo sapiens)
Host	Mouse
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-BFB99A
Similar products	20-783-315465
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Genway ID:	GWB-BFB99A
Specificity:	DECTIN-1
Isotype:	IgG1
Preparation:	Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution:	Phosphate buffered saline pH7. 4
Preservative Stabilisers:		0. 09% Sodium Azide (NaN3) 1% Bovine Serum AlbuminApprox. Protein Concentrations: IgG concentration 0. 1mg/ml
Immunogen:	NIH3T3 cells expressing full length Beta-glucan receptor.
Specificity:	Recognises human Dectin-1 also known as beta-glucan receptor (& #223; GR) a C-type lectin domain family member. It is a major pathogen pattern-recognition receptor that binds beta-glucans glucose polymers that form cell-wall components or exopolymers of yeasts fungi and some bacteria. Beta-glucans have also been used experimentally and therapeutically as immunomodulators that enhance resistance to bacterial yeast viral and protozoan infections as well as tumor formation. Dectin-1 also acts as a co-stimulatory molecule on T-cells to induce their proliferation and is necessary for the TLR2-mediated inflammatory response. It is highly expressed on peripheral blood leukocytes and dendritic cells. Human Dectin-1 has two major (& #223; GR-A and & #223; GR-B) and several minor isoforms. & #223; GR-A and & #223; GR-B differs by the presence and absence respectively of a stalk region.
Specificity:	(clone GE2) Recognises both of these isoforms. Clone GE2 could be used to inhibit receptor function. Recommended for functional assays. Recommended Negative Controls: MOUSE IgG1 NEGATIVE CONTROL:RPE [1] \" ARC an inhibitor of apoptosis expressed in skeletal muscle and heart that interacts selectively with caspases. \" Koseki T. Inohara N. Chen S. Nunez G. Proc. Natl. Acad. Sci. U. S. A. 95:5156-5160(1998) [PubMed: 9560245] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2) INTERACTION WITH CASP2; CASP8; NPM1 AND SFRS9. [2] \" Alternative splicing determines the intracellular localization of the novel nuclear protein Nop30 and its interaction with the splicing factor SRp30c. \" Stoss O. Schwaiger F. -W. Cooper T. A. Stamm S. J. Biol. Chem. 274:10951-10962(1999) [PubMed: 10196175] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2). Tissue: Cervix carcinoma. [3] \" The status quality and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). \" The MGC Project TeamGenome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Kidney.

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