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Rabbit anti Mouse Raptor (CT)

Rabbit anti Mouse Raptor (CT)

ArtNr	18-511-244457
Hersteller	GENWAY
Menge	0,1 mg
Kategorie	Oncology Antibodies By Cell Type Carcinoma Hematology Lymphoma Cell Biology Cell Status Western Blot Autophagy Primary Antibodies By Organ Lung Cancer
Typ	Antibody
Applikationen	WB
Specific against	Mouse (Murine, Mus musculus)
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-1D5B82
Similar products	18-511-244457
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Genway ID:	GWB-1D5B82
Host Animal:	Rabbit
Immunogen:	16 amino acid peptide from near the carboxy-terminus of mouse Raptor (Genbank accession No. Q8K4Q0)
Specificity:	Regulatory Associated Protein of TOR C-terminal
Specificity:	Reacts with Mouse Raptor C-terminal (Regulatory associated protein of TOR). Raptor has multiple isoforms that may be recognized.
Type of Product:	Polyclonal Antibodies to Apoptosis and Signal Transduction Reagents
Concentration:	Lot specificPreservatives: NaN3
Buffer:	PBSApplications Notes : Suitable for use in Western blot (2ug/ml). Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.
Warning:	This product contains sodium azide which has been classified as Xn (Harmful) in European Directive 67/548/EEC in the concentration range of 0. 1â ??1. 0%. When disposing of this reagent through lead or copper plumbing flush with copious volumes of water to prevent azide build-up in drains. Rabbit anti Mouse Raptor (CT). Rabbit Antibody to Mouse Raptor C-terminal
Function:	Participates in the FRAP1 pathway and associates in a near stoichiometric ratio with FRAP1 to form a nutrient-sensitive complex (NSC). Plays a pivotal role as a scaffold protein in the FRAP1-signaling pathway and this interaction is essential for the catalyzed phosphorylation of EIF4EBP1. Has a positive role in nutrient-stimulated signaling to the downstream effector RPS6KB1. Under nutrient-deprived conditions serves as a negative regulator of FRAP1 kinase activity. Regulation of the interaction with FRAP1 is a critical mechanism by which cells coordinate the rate of cell growth and maintenance of cell size with different environmental conditions.
Subunit:	Binds directly 4EBP1 and RPS6KB1 independently of its association with FRAP1. Binds preferentially to poorly or non-phosphorylated form of EIF4EBP1 and this binding is critical to the ability of FRAP1 to catalyze phosphorylation. Complex with FRAP1 physically interacts under both leucine-rich and -poor conditions and therefore in at least two nutrient-determined states with different stability.
Tissue Specificity:	Highly expressed in skeletal muscle and in a lesser extent in brain lung small intestine kidney and placenta.
Miscellaneous:	Rapamycin destabilizes the interaction with FRAP1 regardless of nutrient availability and its potency for dissociation is increased under nutrient-rich conditions. This action uncouples FRAP1 from its substrates and inhibits FRAP1 signaling without altering its intrinsic catalytic activity.
Similarity:	Contains 7 WD repeats.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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Menge: 0,1 mg

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