Mouse CD4 (L3T4)

ArtNr	20-511-242033
Hersteller	GENWAY
Menge	0.2mg
Kategorie	Oncology Neuroscience Aging & Neurological Disorders Antibodies By Cell Type Carcinoma Hematology Leukemia Lymphoma Flow Cytometry Immunoprecipitation Immunofluorescence Primary Antibodies By Organ Heart & Blood Cancer
Typ	Antibody
Applikationen	FC, IF, IP
Clon	GK1. 5
Specific against	Mouse (Murine, Mus musculus)
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-1E1DFE
Similar products	20-511-242033
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Genway ID:	GWB-1E1DFE
Isotype:	IgG2b (Rat)
Clone:	GK1. 5Host Animal: Rat. Hybridization of SP2/0 myeloma cells with spleen cells from Rat.
Immunogen:	Lyt-2-negative T-cell clone 243/2. 5
Specificity:	Recognizes a determinant designated L3T4 present on mouse T-cell surface with an apparent molecular mass of 52kDa. The L3T4 antigen is expressed by the helper/inducer subset of mouse T-cells. The antigen is present on approximately 80% of thymocytes. 20% of spleen cells and 60% of lymph node cells. The expression of L3T4 correlates with class II MHC antigen reactivity on cloned T-cell lines.
Type of Product:	Monoclonal Antibodies to Non-Human CDs
Concentration:	0. 5mg/ml (OD280nm)Preservatives: NaN3
Buffer:	0. 01M PBS pH 7. 4 containing 1% BSA. Applications Notes : Useful for studies of T-helper cell functions including blocking of T-helper cell activation. The anti CD4 antibody can be used for FACS analysis immunofluorescence depletion and immunoprecipitation. We recommend using 1ug to stain 1. 0 x 106 cells in flow cytometric application. Each laboratory should determine their own working dilution for individual use. Other applications have not been tested but use in such assays should not necessarily be excluded.
Warning:	This product contains sodium azide which has been classified as Xn (Harmful) in European Directive 67/548/EEC in the concentration range of 0. 1â ??1. 0%. When disposing of this reagent through lead or copper plumbing flush with copious volumes of water to prevent azide build-up in drains. MAb to Mouse CD4 (L3T4). Monoclonal Antibody to Mouse CD4 (L3T4). Biotin conjugated
Function:	Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts.
Subunit:	Associates with LCK. Binds to HIV-1 gp120 and to P4HB/PDI and upon HIV-1 binding to the cell membrane is part of P4HB/PDI-CD4-CXCR4-gp120 complex. Interacts with HIV-1 Envelope polyprotein gp160 and protein Vpu. Interacts with Human Herpes virus 7 capsid proteins.
Subcellular Location:	Cell membrane; Single-pass type I membrane protein. Note=Localizes to lipid rafts. Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with and sequesters CD4 in the endoplasmic reticulum.
Ptm:	Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts.
Miscellaneous:	Primary receptor for HIV-1.
Similarity:	Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
Similarity:	Contains 1 Ig-like V-type (immunoglobulin-like) domain.

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