Mouse Monoclonal Antibody to PARP

This gene encodes a chromatin-associated enzyme poly(ADP-ribosyl)transferase which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation proliferation and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition this enzyme may be the site of mutation in Fanconi anemia and may participate in the pathophysiology of type I diabetes.

7A10

Ascitic fluid containing 0. 03% sodium azide.

1/200 - 1/400.
ELISA: Propose dilution 1/10000. Not yet tested in other applications. Determining optimal working dilutions by titration test. 1. Cytogenet Cell Genet. 1992; 61(3):172-4. 2. J Immunol. 1997 Dec 1; 159(11):5246-52. 3. J Biol Chem. 2001 Dec 7; 276(49):45588-97.