HAMSTER ANTI MOUSE CD278

CD278

Purified IgG prepared by affinity chromatography

Recognises CD278 also known as Inducible T cell costimulator or ICOS a CD28-superfamily costimulatory molecule. It is expressed on activated T cells and resting memory T cells. It enhances all the basic T cell responses to a foreign antigen namely proliferation secretion of lymphokines and up-regulation of molecules that mediate cell-cell interaction. It is essential for the efficient interaction between B and T cells and is involved in antibody responses to T cell dependent antigens. It up-regulates the synthesis of interleukin-10 but not interleukin-2 and prevents the apoptosis of pre-activated T cells. Clone C398. 4A has been reported to costimulate T cell activation and proliferation in vitro. Recommended Negative Controls: HAMSTER (ARMENIAN) IgG NEGATIVE CONTROLRecommended Secondary Antibodies: Goat Anti Hamster IgG 1. Vogel W. F. et al. (2006) Sensing extracellular matrix: an update on discoidin domain receptor function. Cell Signal. 18:1108-1116. [1] \" Molecular cloning of trkE a novel trk-related putative tyrosine kinase receptor isolated from normal human keratinocytes and widely expressed by normal human tissues. \" di Marco E. Cutuli N. Guerra L. Cancedda R. de Luca M. J. Biol. Chem. 268:24290-24295(1993) [PubMed: 8226977] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Tissue: Brain and Keratinocyte. [2] \" A receptor tyrosine kinase found in breast carcinoma cells has an extracellular discoidin I-like domain. \" Johnson J. D. Edman J. C. Rutter W. J. Proc. Natl. Acad. Sci. U. S. A. 90:5677-5681(1993) [PubMed: 8390675] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1) VARIANT VAL-833. Tissue: Placenta. [3] \" Isolation and characterization of an epithelial-specific receptor tyrosine kinase from an ovarian cancer cell line. \" Laval S. Butler R. Shelling A. N. Hanby A. M. Poulsom R. Ganesan T. S. Cell Growth Differ. 5:1173-1183(1994) [PubMed: 7848919] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2) TISSUE SPECIFICITY. Tissue: Ovary. [4] \" Identification and chromosomal mapping of a receptor tyrosine kinase with a putative phospholipid binding sequence in its ectodomain. \" Perez J. L. Shen X. Finkernagel S. Sciorra L. Jenkins N. A. Gilbert D. J. Copeland N. G. Wong T. W. Oncogene 9:211-219(1994) [PubMed: 8302582] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Fetal liver. [5] \" Receptor protein tyrosine kinase DDR is up-regulated by p53 protein. \" Sakuma S. Tada M. Saya H. Sawamura Y. Shinohe Y. Abe H. FEBS Lett. 398:165-169(1996) [PubMed: 8977099] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] VARIANT VAL-833. [6] \" The genomic structure of discoidin receptor tyrosine kinase. \" Playford M. P. Butler R. J. Wang X. C. Katso R. M. Cooke I. E. Ganesan T. S. Genome Res. 6:620-627(1996) [PubMed: 8796349] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. [7] \" Identification of two isoforms of the Cak receptor kinase that are coexpressed in breast tumor cell lines. \" Perez J. L. Jing S. Q. Wong T. W. Oncogene 12:1469-1477(1996) [PubMed: 8622863] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Tissue: Lung. [8] \" Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis. \" Jin P. Zhang J. Sumariwalla P. F. Ni I. Jorgensen B. Crawford D. Phillips S. Feldmann M. Shepard H. M. Paleolog E. M. Arthritis Res. Ther. 10:R73-R73(2008) [PubMed: 18593464] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3) NUCLEOTIDE SEQUENCE [MRNA] OF 1-286 (ISOFORMS 1/2/4). [9] \" Complete sequencing and characterization of 21 243 full-length human cDNAs. \" Ota T. Suzuki Y. Nishikawa T. Otsuki T. Sugiyama T. Irie R. Wakamatsu A. Hayashi K. Sato H. Nagai K. Kimura K. Makita H. Sekine M. Obayashi M. Nishi T. Shibahara T. Tanaka T. Ishii S. Yamamoto J. Saito K. Kawai Y. Isono Y. Nakamura Y. Nagahari K. Murakami K. Yasuda T. Iwayanagi T. Wagatsuma M. Shiratori A. Sudo H. Hosoiri T. Kaku Y. Kodaira H. Kondo H. Sugawara M. Takahashi M. Kanda K. Yokoi T. Furuya T. Kikkawa E. Omura Y. Abe K. Kamihara K. Katsuta N. Sato K. Tanikawa M. Yamazaki M. Ninomiya K. Ishibashi T. Yamashita H. Murakawa K. Fujimori K. Tanai H. Kimata M. Watanabe M. Hiraoka S. Chiba Y. Ishida S. Ono Y. Takiguchi S. Watanabe S. Yosida M. Hotuta T. Kusano J. Kanehori K. Takahashi-Fujii A. Hara H. Tanase T. -O. Nomura Y. Togiya S. Komai F. Hara R. Takeuchi K. Arita M. Imose N. Musashino K. Yuuki H. Oshima A. Sasaki N. Aotsuka S. Yoshikawa Y. Matsunawa H. Ichihara T. Shiohata N. Sano S. Moriya S. Momiyama H. Satoh N. Takami S. Terashima Y. Suzuki O. Nakagawa S. Senoh A. Mizoguchi H. Goto Y. Shimizu F. Wakebe H. Hishigaki H. Watanabe T. Sugiyama A. Takemoto M. Kawakami B. Yamazaki M. Watanabe K. Kumagai A. Itakura S. Fukuzumi Y. Fujimori Y. Komiyama M. Tashiro H. Tanigami A. Fujiwara T. Ono T. Yamada K. Fujii Y. Ozaki K. Hirao M. Ohmori Y. Kawabata A. Hikiji T. Kobatake N. Inagaki H. Ikema Y. Okamoto S. Okitani R. Kawakami T. Noguchi S. Itoh T. Shigeta K. Senba T. Matsumura K. Nakajima Y. Mizuno T. Morinaga M. Sasaki M. Togashi T. Oyama M. Hata H. Watanabe M. Komatsu T. Mizushima-Sugano J. Satoh T. Shirai Y. Takahashi Y. Nakagawa K. Okumura K. Nagase T. Nomura N. Kikuchi H. Masuho Y. Yamashita R. Nakai K. Yada T. Nakamura Y. Ohara O. Isogai T. Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Placenta. [10] \" Preparation of a set of expression-ready clones of mammalian long cDNAs encoding large proteins by the ORF trap cloning method. \" Nakajima D. Saito K. Yamakawa H. Kikuno R. F. Nakayama M. Ohara R. Okazaki N. Koga H. Nagase T. Ohara O. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.