RAT ANTI MOUSE CD51:RPE

GWB-EAD000

IgG1

Phosphate buffered saline pH7. 4

cultured LAK cells from Balb/c mice.

The alpha-V integrins are receptors for vitronectin cytotactin fibronectin fibrinogen laminin matrix metalloproteinase-2 osteopontin osteomodulin prothrombin thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. Alpha-V integrins may play a role in embryo implantation angiogenesis and wound healing. Mice expressing a null mutation of the alpha-V subunit gene survive until late in embryonic development and occasionally even to birth. They demonstrate cleft palate and defective development of CNS and gastrointestinal blood vessels. Subunit structureInteracts with RAB25 By similarity. Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-V associates with either beta-1 beta-3 beta-5 beta-6 or beta-8. Subcellular locationMembrane; Single-pass type I membrane protein. Sequence similaritiesBelongs to the integrin alpha chain family. Contains 7 FG-GAP repeats. [1] \" The transcriptional landscape of the mammalian genome. \" Carninci P. Kasukawa T. Katayama S. Gough J. Frith M. C. Maeda N. Oyama R. Ravasi T. Lenhard B. Wells C. Kodzius R. Shimokawa K. Bajic V. B. Brenner S. E. Batalov S. Forrest A. R. Zavolan M. Davis M. J. Wilming L. G. Aidinis V. Allen J. E. Ambesi-Impiombato A. Apweiler R. Aturaliya R. N. Bailey T. L. Bansal M. Baxter L. Beisel K. W. Bersano T. Bono H. Chalk A. M. Chiu K. P. Choudhary V. Christoffels A. Clutterbuck D. R. Crowe M. L. Dalla E. Dalrymple B. P. de Bono B. Della Gatta G. di Bernardo D. Down T. Engstrom P. Fagiolini M. Faulkner G. Fletcher C. F. Fukushima T. Furuno M. Futaki S. Gariboldi M. Georgii-Hemming P. Gingeras T. R. Gojobori T. Green R. E. Gustincich S. Harbers M. Hayashi Y. Hensch T. K. Hirokawa N. Hill D. Huminiecki L. Iacono M. Ikeo K. Iwama A. Ishikawa T. Jakt M. Kanapin A. Katoh M. Kawasawa Y. Kelso J. Kitamura H. Kitano H. Kollias G. Krishnan S. P. Kruger A. Kummerfeld S. K. Kurochkin I. V. Lareau L. F. Lazarevic D. Lipovich L. Liu J. Liuni S. McWilliam S. Madan Babu M. Madera M. Marchionni L. Matsuda H. Matsuzawa S. Miki H. Mignone F. Miyake S. Morris K. Mottagui-Tabar S. Mulder N. Nakano N. Nakauchi H. Ng P. Nilsson R. Nishiguchi S. Nishikawa S. Nori F. Ohara O. Okazaki Y. Orlando V. Pang K. C. Pavan W. J. Pavesi G. Pesole G. Petrovsky N. Piazza S. Reed J. Reid J. F. Ring B. Z. Ringwald M. Rost B. Ruan Y. Salzberg S. L. Sandelin A. Schneider C. Schoenbach C. Sekiguchi K. Semple C. A. Seno S. Sessa L. Sheng Y. Shibata Y. Shimada H. Shimada K. Silva D. Sinclair B. Sperling S. Stupka E. Sugiura K. Sultana R. Takenaka Y. Taki K. Tammoja K. Tan S. L. Tang S. Taylor M. S. Tegner J. Teichmann S. A. Ueda H. R. van Nimwegen E. Verardo R. Wei C. L. Yagi K. Yamanishi H. Zabarovsky E. Zhu S. Zimmer A. Hide W. Bult C. Grimmond S. M. Teasdale R. D. Liu E. T. Brusic V. Quackenbush J. Wahlestedt C. Mattick J. S. Hume D. A. Kai C. Sasaki D. Tomaru Y. Fukuda S. Kanamori-Katayama M. Suzuki M. Aoki J. Arakawa T. Iida J. Imamura K. Itoh M. Kato T. Kawaji H. Kawagashira N. Kawashima T. Kojima M. Kondo S. Konno H. Nakano K. Ninomiya N. Nishio T. Okada M. Plessy C. Shibata K. Shiraki T. Suzuki S. Tagami M. Waki K. Watahiki A. Okamura-Oho Y. Suzuki H. Kawai J. Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4). Strain: C57BL/6 C57BL/6J and NOD. Tissue: Brain. [2] \" Lineage-specific biology revealed by a finished genome assembly of the mouse. \" Church D. M. Goodstadt L. Hillier L. W. Zody M. C. Goldstein S. She X. Bult C. J. Agarwala R. Cherry J. L. DiCuccio M. Hlavina W. Kapustin Y. Meric P. Maglott D. Birtle Z. Marques A. C. Graves T. Zhou S. Teague B. Potamousis K. Churas C. Place M. Herschleb J. Runnheim R. Forrest D. Amos-Landgraf J. Schwartz D. C. Cheng Z. Lindblad-Toh K. Eichler E. E. Ponting C. P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed: 19468303] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6. [3] \" The status quality and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). \" The MGC Project TeamGenome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). Tissue: Embryo. [4] \" Role of mouse RREB gene in cancer susceptibility/resistance. \" Zhang S. Bliskovsky V. Mock B. Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [MRNA] OF 21-1700 (ISOFORM 3). Strain: BALB/c. [5] \" p16 INK4a gene promoter variation and differential binding of a repressor the ras-responsive zinc-finger transcription factor RREB. \" Zhang S. Qian X. Redman C. Bliskovski V. Ramsay E. S. Lowy D. R. Mock B. A. Oncogene 22:2285-2295(2003) [PubMed: 12700664] [Abstract]Cited for: FUNCTION TISSUE SPECIFICITY. [6] \" Large-scale phosphorylation analysis of mouse liver. \" Villen J. Beausoleil S. A. Gerber S. A. Gygi S. P. Proc. Natl. Acad. Sci. U. S. A. 104:1488-1493(2007) [PubMed: 17242355] [Abstract]Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1137; SER-1138; SER-1179; SER-1180 AND SER-1452 MASS SPECTROMETRY. Tissue: Liver.