CDX2 (caudal type homeobox transcription factor 2)

GWB-679B8B

1:312500

Involved in the transciptional regulation of multiple genes expressed in the intestinal epithelium. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine.

Phosphorylation of Ser-60 mediates the transactivation capacity (By similarity).

Contains 1 homeobox DNA-binding domain. Summary: The level and beta-cell specificity of insulin gene expression are regulated by a set of nuclear proteins that bind to specific sequences within the promoter of the insulin gene (INS; MIM 176730) and interact with RNA polymerase to activate or repress transcription. The proteins LMX1 (MIM 600298) and CDX3 are homeodomain proteins that bind an A/T-rich sequence in the insulin promoter and stimulate its transcription (German et al. 1994 [PubMed 7698771]). [supplied by OMIM]. Saad. R. S. . et al. . (2004) J. Clin. Pathol. 122 (3). 421-427.