LEF1 (lymphoid enhancer-binding factor 1)

Polyclonal antibody produced in rabbits immunized with a synthetic peptide corresponding to a region of human LEF1.

Beta-Scaffold Factors with Minor Grove Contacts

Participates in the Wnt signaling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300. May play a role in hair cell differentiation and follicle morphogenesis. TLE1 TLE2 TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1. Regulates T-cell receptor alpha enhancer function. Binds DNA in a sequence-specific manner. PIAG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity). Isoform 3 lacks the CTNNB1 interaction domain and may be an antagonist for Wnt signaling.

Nucleus (By similarity). Note=Found in nuclear bodies upon PIASG binding (By similarity).

Proline-rich and acidic regions are implicated in the activation functions of RNA polymerase II transcription factors.

Contains 1 HMG box DNA-binding domain. Summary: Lymphoid enhancer-binding factor-1 (LEF1) is a 48-kD nuclear protein that is expressed in pre-B and T cells. It binds to a functionally important site in the T-cell receptor-alpha (TCRA; MIM 186880) enhancer and confers maximal enhancer activity. LEF1 belongs to a family of regulatory proteins that share homology with high mobility group protein-1 (HMG1; MIM 163905). [supplied by OMIM]. Liu. X. . et al. . (2004) J. Invest. Dermatol. 123 (2). 264-274.