PARP3 (poly (ADP-ribose) polymerase family. member 3)

GWB-D813BA

1:62500

Involved in the base excision repair (BER) pathway by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication.

Interacts with PARP1. Binds DNA.

Widely expressed; the highest levels are in the kidney skeletal muscle liver heart and spleen; also detected in pancreas lung placenta brain leukocytes colon small intestine ovary testis prostate and thymus.

Auto-poly(ADP)-ribosylation.

Contains 1 PARP catalytic domain. Summary: The protein encoded by this gene belongs to the PARP family. These enzymes modify nuclear proteins by poly-ADP-ribosylation which is required for DNA repair regulation of apoptosis and maintenance of genomic stability. This protein is the poly(ADP-ribosyl)transferase 3 which is preferentially localized to the daughter centriole throughout the cell cycle. Alternatively spliced transcript variants encoding different isoforms have been identified. Augustin. A. . et al. . (2003) J. Cell. Sci. 116 (Pt 8). 1551-1562.