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HEXIM1 (hexamethylene bis-acetamide inducible 1)

HEXIM1 (hexamethylene bis-acetamide inducible 1)

ArtNr	18-003-42525
Hersteller	GENWAY
Menge	0.1 mg
Kategorie	Oncology Antibodies Western Blot Primary Antibodies By Organ Skin Cancer
Typ	Antibody
Applikationen	WB
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-8A4CB8
Similar products	18-003-42525
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Genway ID:	GWB-8A4CB8
Antigen Specificity:	Polyclonal antibody produced in rabbits immunized with a synthetic peptide corresponding to a region of Human HEXIM1.
ELISA Titre:	1:12500Western Blot: Suggested dilution at 0. 6 microg/ml in 5% skim milk / PBS buffer. and HRP conjugated anti-Rabbit IgG should be diluted in 1: 50. 000 - 100. 000 as second antibody.
Note:	Suggested starting concentrations are provided. Optimal dilutions should be determined by end-user. Differences in calculated versus apparent molecular weight may be due to post-translational modifications or protein hydrophobicity. HEXIM1 expression is induced by hexamethylene-bis-acetamide in vascular smooth muscle cells. The function of this protein is not yet known.
Function:	Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. May also regulate NF-kappa-B ESR1 NR3C1 and CIITA-dependent transcriptional activity.
Subunit:	Homooligomer and heterooligomer with HEXIM2; probably dimeric. Component of the 7SK snRNP complex at least composed of P-TEFb (composed of CDK9 and CCNT1/cyclin-T1) HEXIM1 HEXIM2 BCDIN3 SART3 proteins and 7SK and U6 snRNAs. Interacts with the N-CoR complex through NCOR1. Interacts with ESR1 and NR3C1. May interact with NF-kappa-B through RELA.
Subcellular Location:	Nucleus. Cytoplasm. Note=Binds alpha-importin and is mostly nuclear.
Tissue Specificity:	Ubiquitously expressed with higher expression in placenta. HEXIM1 and HEXIM2 are differentially expressed. Expressed in endocrine tissues.
Induction:	Up-regulated by HMBA (hexamethylene bisacetamide) (at protein level). Down-regulated by estrogen.
Domain:	The coiled-coil domain mediates oligomerization.
Miscellaneous:	Inhibits Tat activity which is required for HIV-1 transcription.
Similarity:	Belongs to the HEXIM family. Summary: Expression of this gene is induced by hexamethylene-bis-acetamide in vascular smooth muscle cells. This protein has no introns. Yik. J. H. . et al. . (2003) Mol. Cell 12 (4). 971-982.

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Menge: 0.1 mg

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