EPLIN

ArtNr	18-003-42549
Hersteller	GENWAY
Menge	0.05 mg
Kategorie	Oncology Antibodies Western Blot Primary Antibodies By Organ Lung Cancer
Typ	Antibody
Applikationen	WB
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-3E6EB5
Similar products	18-003-42549
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Genway ID:	GWB-3E6EB5
Antigen Specificity:	Polyclonal antibody produced in rabbits immunized with a synthetic peptide corresponding to a region of Human EPLIN.
ELISA Titre:	1:12500
Note:	Suggested starting concentrations are provided. Optimal dilutions should be determined by end-user. Differences in calculated versus apparent molecular weight may be due to post-translational modifications or protein hydrophobicity. EPLIN is a cytoskeleton-associated protein that inhibits actin filament depolymerization and cross-links filaments in bundles (Maul et al. . 2003 [PubMed 12566430]). [supplied by OMIM].
Function:	Binds to actin monomers and filaments. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments delays filament nucleation and reduces formation of branched filaments.
Subcellular Location:	Cytoplasm. Cell junction focal adhesion. Cytoplasm cytoskeleton. Note=This cytoskeletal protein co-localizes with actin stress fibers and focal adhesion plaques.
Tissue Specificity:	Highly expressed in placenta kidney pancreas prostate ovary spleen and heart. Also detected in lung liver brain skeletal muscle thymus testis and intestine. Not detected in leukocytes. Isoform Beta expressed generally at very low levels. Isoform Alpha abundant in epithelial cells from mammary gland prostate and in normal oral keratinocytes. Low levels in aortic endothelial cells and dermal fibroblasts. Not detectable in myocardium.
Induction:	Down-regulated in some cancer cell lines. Isoform Alpha induced by serum. Isoform Beta constitutively expressed.
Domain:	Contains at least 2 actin-binding domains one on each side of the LIM domain. Both domains bind actin monomers and filaments. The C-terminal domain binds filaments more efficiently than the N-terminus.
Similarity:	Contains 1 LIM zinc-binding domain. Summary: EPLIN is a cytoskeleton-associated protein that inhibits actin filament depolymerization and cross-links filaments in bundles (Maul et al. 2003 [PubMed 12566430]). [supplied by OMIM]. Maul. R. S. . et al. . (2003) J. Cell Biol. 160 (3). 399-407.

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Menge: 0.05 mg

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