ZFPM1

Polyclonal antibody produced in rabbits immunized with a synthetic peptide corresponding to a region of Mouse Zfpm1. Western Blot: Antibody

MSRRKQSNPRQIKRSLRDMEAGEEAKAMDSSPKEQEAPDPEAPAIEEPPS

Add 50ul of distilled water to this antibody before use.

Suggested starting concentrations are provided. Optimal dilutions should be determined by end-user. Differences in calculated versus apparent molecular weight may be due to post-translational modifications or protein hydrophobicity. Zfpm1 is a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. It is essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family. Zfpm1 may be involved in regulation of some genes in gonades and involed in cardiac development in a non-redundant way with ZFPM2/FOG2.

Interacts with the N-terminal zinc-finger of GATA1 GATA2 and GATA3. Interacts with corepressor CTBP2; this interaction is however not essential for corepressor activity in erythropoiesis. Interacts with TACC3.

Mainly expressed in hematopoietic tissues. Expressed in the spleen a primary site of hematopoiesis in the adult mouse as well as in the liver and testis but not in the heart brain lung kidney or skeletal muscle. Among hematopoietic cell lines it is strongly expressed in erythroid and megakaryocytic cell lines. Expressed at low level in several lymphoid and early myeloid cell lines. Not expressed in mast cell and macrophage lines. Expressed in the heart where it colocalizes with GATA4 GATA5 and GATA6. Developmental Stage: First expressed in two extraembryonic mesodermal derivatives the yolk sac and the allantois in E8. 5 embryos. Localized to the embryonic red blood cells within the yolk sac blood islands.

Phosphorylated upon DNA damage probably by ATM or ATR (By similarity).

Contains 4 C2H2-type zinc fingers.