SCN3B (sodium channel. voltage-gated. type III. beta)

Polyclonal antibody produced in rabbits immunized with a synthetic peptide corresponding to a region of Human SCN3B. Western Blot: Suggested dilution at 0. 5ug/ml in 5% skim milk / PBS buffer and HRP conjugated anti-Rabbit should be diluted in 1:50 000 - 100 000 as second antibody.

Suggested starting concentrations are provided. Optimal dilutions should be determined by end-user. Differences in calculated versus apparent molecular weight may be due to post-translational modifications or protein hydrophobicity. SCN3B is one member of the sodium channel beta subunits of voltage-gated sodium channels. which are responsible for the generation and propagation of action potentials in neurons and muscle. SCN3B influences the inactivation kinetics of the sodium channel

The voltage-sensitive sodium channel consists of an ion conducting pore forming alpha-subunit regulated by one or more beta-1 beta-2 and/or beta-3 subunits. Beta-1 and beta-3 are non-covalently associated with alpha while beta-2 is covalently linked by disulfide bonds. Beta-1 or beta-3 subunits associate with neurofascin. Associates with SCN10A (By similarity).

Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Summary: Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This protein is one member of the sodium channel beta subunit gene family and influences the inactivation kinetics of the sodium channel. Two alternatively spliced variants encoding the same protein have been identified. Kimura. K. . et al. . (2006) Genome Res. 16 (1). 55-65.