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DCP1A (DCP1 decapping enzyme homolog A (S. cerevisiae))

DCP1A (DCP1 decapping enzyme homolog A (S. cerevisiae))

ArtNr	18-003-43271
Hersteller	GENWAY
Menge	0.1 mg
Kategorie	Oncology Neuroscience Aging & Neurological Disorders Antibodies Western Blot Cardiovascular Research Heart Failure Myocardial Infarction Primary Antibodies By Organ Lung Cancer
Typ	Antibody
Applikationen	WB
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-ACCA0E
Similar products	18-003-43271
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Genway ID:	GWB-ACCA0E
Antigen Specificity:	Polyclonal antibody produced in rabbits immunized with a synthetic peptide corresponding to a region of Human DCP1A.
ELISA Titre:	1:312500
Note:	Suggested starting concentrations are provided. Optimal dilutions should be determined by end-user. Differences in calculated versus apparent molecular weight may be due to post-translational modifications or protein hydrophobicity. Decapping is a key step in general and regulated mRNA decay. The protein encoded by this gene is a decapping enzyme. This protein and another decapping enzyme form a decapping complex. which interacts with the nonsense-mediated decay factor hUpf1 and may
Function:	Necessary for the degradation of mRNAs both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules yielding a 5\' -phosphorylated mRNA fragment and 7m-GDP. Contributes to the transactivation of target genes after stimulation by TGFB1.
Subunit:	Forms a complex with EDC3 DCP2 DDX6 and EDC4/HEDLS within this complex directly interacts with EDC3. Binds DCP1B UPF1 and SMAD4. Part of a cytoplasmic complex containing proteins involved in mRNA decay including XRN1 and LSM1.
Subcellular Location:	Cytoplasm P-body. Nucleus. Note=Predominantly cytoplasmic in processing bodies (PB). Nuclear after TGFB1 treatment. Translocation to the nucleus depends on interaction with SMAD4.
Tissue Specificity:	Detected in heart brain placenta lung skeletal muscle liver kidney and pancreas.
Similarity:	Belongs to the DCP1 family. Summary: Decapping is a key step in general and regulated mRNA decay. The protein encoded by this gene is a decapping enzyme. This protein and another decapping enzyme form a decapping complex which interacts with the nonsense-mediated decay factor hUpf1 and may be recruited to mRNAs containing premature termination codons. This protein also participates in the TGF-beta signaling pathway. Lehner. B. (2004) Genome Res. 14 (7). 1315-1323.

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Menge: 0.1 mg

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