DLX3 (distal-less homeobox 3)

GWB-993293

1:1562500

Suggested starting concentrations are provided. Optimal dilutions should be determined by end-user. Differences in calculated versus apparent molecular weight may be due to post-translational modifications or protein hydrophobicity. DLX3 is a member of the Dlx gene family which contains a homeobox that is related to that of Distal-less (Dll). a gene expressed in the head and limbs of the developing fruit fly. The Distal-less homeo box(Dlx) family of genes comprises at least 6 differe

Nucleus (Potential).

Defects in DLX3 are a cause of amelogenesis imperfecta hypomaturation-hypoplastic type with taurodontism (AIHHT) [MIM:104510]. AIHHT is an autosomal dominant defect of enamel formation associated with enlarged pulp chambers.

Contains 1 homeobox DNA-binding domain. Summary: Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll) a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members DLX1-DLX6. Trichodentoosseous syndrome (TDO) an autosomal dominant condition has been correlated with DLX3 gene mutation. This protein is located in a tail-to-tail configuration with another member of the gene family on the long arm of chromosome 17. Mutations in this gene have been associated with the autosomal dominant conditions trichodentoosseous syndrome and amelogenesis imperfecta with taurodontism. Maruyama. K. (2006) Calcif. Tissue Int. 78 (2). 98-102.