AGER (advanced glycosylation end product-specific receptor)

Polyclonal antibody produced in rabbits immunized with a synthetic peptide corresponding to a region of Human AGER. Western Blot: Suggested dilution at 2. 5 microg/ml in 5% skim milk / PBS buffer. and HRP conjugated anti-Rabbit IgG should be diluted in 1: 50. 000 - 100. 000 as second antibody.

1:62500

Suggested starting concentrations are provided. Optimal dilutions should be determined by end-user. Differences in calculated versus apparent molecular weight may be due to post-translational modifications or protein hydrophobicity. AGER mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. It is receptor for amyloid beta peptide. This genSummary: This protein is a member of the immunoglobulin superfamily of cell surface molecules. It is a receptor for various molecules including the amyloidogenic form of serum amyloid A amyloid-beta protein members of the S100/calgranulin superfamily and advanced glycation end products. The gene lies within the major histocompatibility complex (MHC) class III region on chromosome 6. Alternative splicing results in two transcript variants encoding different isoforms. Scherer. S. W. . (2006) Thromb. Haemost. 95 (2). 320-328.