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ALX4 (aristaless-like homeobox 4)

ALX4 (aristaless-like homeobox 4)

ArtNr	18-003-43839
Hersteller	GENWAY
Menge	0.05 mg
Kategorie	Antibodies Western Blot Primary Antibodies
Typ	Antibody
Applikationen	WB
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-A39376
Similar products	18-003-43839
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Genway ID:	GWB-A39376
Antigen Specificity:	Polyclonal antibody produced in rabbits immunized with a synthetic peptide corresponding to a region of Human ALX4.
ELISA Titre:	1:12500
Category:	Transcription Factor Antibodies
Note:	Suggested starting concentrations are provided. Optimal dilutions should be determined by end-user. Differences in calculated versus apparent molecular weight may be due to post-translational modifications or protein hydrophobicity. Alx4 is a member of the family of transcription factors that contain the paired-type homeodomain. In contrast to other types of homeodomains. the paired-type homeodomain has been shown to mediate high-affinity sequence-specific DNA binding to palindromic
Function:	Transcription factor involved in skull and limb development.
Subunit:	Binds DNA (By similarity).
Subcellular Location:	Nucleus (By similarity).
Tissue Specificity:	Expression is likely to be restricted to bone. Found in parietal bone.
Disease:	Defects in ALX4 are the cause of parietal foramina 2 (PFM2) [MIM:609597]; also known as foramina parietalia permagna (FPP). PFM2 is an autosomal dominant disease characterized by oval defects of the parietal bones caused by deficient ossification around the parietal notch which is normally obliterated during the fifth fetal month. PFM2 is also a clinical feature of Potocki-Shaffer syndrome.
Disease:	Involved in Potocki-Shaffer syndrome (PSS) [MIM:601224]. PSS is a contiguous gene syndrome caused by deletion of the 11p11. 2 region.
Similarity:	Belongs to the paired homeobox family.
Similarity:	Contains 1 homeobox DNA-binding domain.
Similarity:	Contains 1 OAR domain. Wakui. K. . et al. . (2005) Eur. J. Hum. Genet. 13 (5). 528-540.

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