SOX2 (SRY (sex determining region Y)-box 2)

GWB-CF53BE

1:1562500

Suggested starting concentrations are provided. Optimal dilutions should be determined by end-user. Differences in calculated versus apparent molecular weight may be due to post-translational modifications or protein hydrophobicity. SOX2 is a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The protein may act as a transcriptional activator after forming a protein complex

Nucleus.

Contains 1 HMG box DNA-binding domain. Summary: This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia a severe form of structural eye malformation. This protein lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT). Lei. J. X. . (2005) Cell Death Differ. 12 (11). 1368-1377.