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CPSF1 (cleavage and polyadenylation specific factor 1. 160kDa)

CPSF1 (cleavage and polyadenylation specific factor 1. 160kDa)

ArtNr	18-003-44459
Hersteller	GENWAY
Menge	0.05 mg
Kategorie	Metabolism Diabetes Antibodies Western Blot Primary Antibodies
Typ	Antibody
Applikationen	WB
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-570DC6
Similar products	18-003-44459
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Genway ID:	GWB-570DC6
Antigen Specificity:	Polyclonal antibody produced in rabbits immunized with a synthetic peptide corresponding to a region of Human CPSF1.
ELISA Titre:	1:62500
Category:	RNA Binding Proteins
Note:	Suggested starting concentrations are provided. Optimal dilutions should be determined by end-user. Differences in calculated versus apparent molecular weight may be due to post-translational modifications or protein hydrophobicity. CPSF1 is a component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3`-end formation. recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about
Function:	Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3\' -end formation recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction.
Subunit:	Component of the cleavage and polyadenylation specificity factor (CPSF) complex composed of CPSF1 CPSF2 CPSF3 CPSF4 and FIP1L1. Found in a complex with CPSF1 FIP1L1 and PAPOLA. Interacts with FIP1L1 and SRRM1.
Subcellular Location:	Nucleus nucleoplasm.
Ptm:	The N-terminus is blocked.
Similarity:	Belongs to the CPSF1 family. Summary: Cleavage and polyadenylation specificity factor (CPSF) is a multisubunit complex that plays a central role in 3-prime processing of pre-mRNAs. CPSF recognizes the AAUAAA signal in the pre-mRNA and interacts with other proteins to facilitate both RNA cleavage and poly(A) synthesis. CPSF1 is the largest subunit of the CPSF complex (Murthy and Manley 1995 [PubMed 7590244]). [supplied by OMIM]. Beausoleil. S. A. . (2004) Proc. Natl. Acad. Sci. U. S. A. 101 (33). 12130-12135.

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Menge: 0.05 mg

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