CA4 (carbonic anhydrase IV)

GWB-564D37

1:312500

Suggested starting concentrations are provided. Optimal dilutions should be determined by end-user. Differences in calculated versus apparent molecular weight may be due to post-translational modifications or protein hydrophobicity. Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes. including respiration. calcification. acid-base balance. bone resorption.

H2CO3 = CO2 + H2O. Cofactor: Zinc.

Interacts with SLC4A4.

Expressed in the endothelium of the choriocapillaris in eyes (at protein level).

Belongs to the alpha-carbonic anhydrase family. Summary: Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes including respiration calcification acid-base balance bone resorption and the formation of aqueous humor cerebrospinal fluid saliva and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA IV is a glycosylphosphatidyl-inositol-anchored membrane isozyme expressed on the luminal surfaces of pulmonary (and certain other) capillaries and of proximal renal tubules. Its exact function is not known however it may have a role in inherited renal abnormalities of bicarbonate transport. Yang. Z. . (2005) Hum. Mol. Genet. 14 (2). 255-265.