GSTM2 (glutathione S-transferase M2 (muscle))

Polyclonal antibody produced in rabbits immunized with a synthetic peptide corresponding to a region of Human GSTM2.

Lyophilized powder
Immunohistochemistry: 4-8ug/ml

Suggested starting concentrations are provided. Optimal dilutions should be determined by end-user. Differences in calculated versus apparent molecular weight may be due to post-translational modifications or protein hydrophobicity. At present. eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha. kappa. mu. omega. pi. sigma. theta and zeta. GSTM2 is a glutathione S-transferase that belongs to the mu class. The mu class of

RX + glutathione = HX + R-S-glutathione.

Cytoplasm.

Belongs to the GST superfamily. Mu family.

Contains 1 GST N-terminal domain. Summary: Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha kappa mu omega pi sigma theta and zeta. This protein is a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds including carcinogens therapeutic drugs environmental toxins and products of oxidative stress by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13. 3 and are known to be highly polymorphic. These genetic variations can change an individual\' s susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Hayek. T. . (2006) Atherosclerosis 184 (2). 404-412.