Bisphosphate 3\'-nucleotidase

06-202-340297 - Immunizing Peptide

1-3ug/ml. Summary: BPNT1 also called bisphosphate 3-prime-nucleotidase or BPntase is a member of a magnesium-dependent phosphomonoesterase family. Lithium a major drug used to treat manic depression acts as an uncompetitive inhibitor of BPntase. The predicted human protein is 92% identical to mouse BPntase. BPntase\' s physiologic role in nucleotide metabolism may be regulated by inositol signaling pathways. The inhibition of human BPntase may account for lithium-induced nephrotoxicity. [provided by RefSeq]. [1] Spiegelberg B. D. Xiong J. P. Smith J. J. Gu R. F. and York J. D. et al. Cloning and characterization of a mammalian lithium-sensitive bisphosphate 3\' -nucleotidase inhibited by inositol 1 4-bisphosphate