NF-M

A00144. 01

For the detection of ubiquitinated inclusions seen in human neurodegennerative diseases such as the neurofibrillary tangles of Alzheimer`s disease. Dilution 1:500 for this purpose. using ABC or other enzymatic amplification procedures. Immunofluorescence Neurofilaments can be defined as the intermediate or 10nm diameter filaments found in neuronal cells. They are composed a mixture of subunits which often includes the neurofilament triplet proteins. NF-L. NF-M and NF-H. Neurofilaments may also include per

There are a number of repeats of the tripeptide K-S-P NFM is phosphorylated on a number of the serines in this motif. It is thought that phosphorylation of NFM results in the formation of interfilament cross bridges that are important in the maintenance of axonal caliber.

Belongs to the intermediate filament family. [1] Levy E. Liem R. K. D\' Eustachio P. and Cowan N. J. et al. Structure and evolutionary origin of the gene encoding mouse NF-M the middle-molecular-mass neurofilament protein[2] Levy E. Liem R. K. H. D\' Eustachio P. Cowan N. J. Structure and evolutionary origin of the gene encoding mouse NF-M the middle-molecular-mass neurofilament protein. [3] Julien J. -P. Meyer D. Flavell D. Hurst J. Grosveld F. Cloning and developmental expression of the murine neurofilament gene family. [4] Collins M. O. Yu L. Coba M. P. Husi H. Campuzano I. Blackstock W. P. Choudhary J. S. Grant S. G. Proteomic analysis of in vivo phosphorylated synaptic proteins. [5] Trinidad J. C. Specht C. G. Thalhammer A. Schoepfer R. Burlingame A. L. Comprehensive identification of phosphorylation sites in postsynaptic density preparations. [6] Vosseller K. Trinidad J. C. Chalkley R. J. Specht C. G. Thalhammer A. Lynn A. J. Snedecor J. O. Guan S. Medzihradszky K. F. Maltby D. A. et al. O-linked N-acetylglucosamine proteomics of postsynaptic density preparations using lectin weak affinity chromatography and mass spectrometry.