P2X1

ArtNr	18-272-195005
Hersteller	GENWAY
Menge	0.05 ml
Kategorie	Oncology Antibodies Immunohistochemistry Immunocytochemistry Primary Antibodies By Organ Skin Cancer
Typ	Antibody
Applikationen	IHC, ICC
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-529B64
Similar products	18-272-195005
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Genway ID:	GWB-529B64
Isotype:	IgG
Immunogen:	Synthetic peptide (GLQENMRTS) corresponding to amino acids 364-372 of Rat P2X1.
Antigen Species:	Rat
Target:	P2X1
Localization:	Plasma membrane Storage
Preservative:	0. 05% Sodium Azide; Constituents: Whole Serum
Application Note:	ICC: Use at a dilution of 1/1000. IHC-Fr: Use at a dilution of 1/1000. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. Cellular
Localization:	Plasma membrane The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel with relatively high calcium permeability. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle being responsible for example for sympathetic vasoconstriction in small arteries arterioles and vas deferens. Mouse studies suggest that this receptor is essential for normal male reproductive function. It is possible that the development of selective antagonists for this receptor may provide an effective non-hormonal male contraceptive pill.
Function:	Ligand gated ion channel with relatively high calcium permeability. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Seems to be linked to apoptosis by increasing the intracellular concentration of calcium in the presence of ATP leading to programmed cell death (By similarity).
Subunit:	Homo- or heteropolymers (By similarity).
Subcellular Location:	Membrane; Multi-pass membrane protein.
Disease:	Defects in P2RX1 are a cause of bleeding disorder [MIM:600845].
Similarity:	Belongs to the P2X receptor family.

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