mGluR5

GWB-B1B8CD

Synthetic peptide: YDRRLAQHKSEIE.

0. 1% Sodium Azide; Constituents: 1. 0% BSA

132. 1 kDa. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. The metabotropic glutamate receptors (mGluRs) are G protein-coupled receptors (GPCRs) that contain 7 membrane-spanning domains and a large extracellular N-terminal region. The group I receptors mGluR1 and mGluR5 activate phospholipase C. By screening a human brain cDNA library with a rat mGluR1-alpha cDNA under low stringency conditions Minakami et al. (1993) and Minakami et al. (1994) isolated human cDNAs encoding mGluR5. Minakami et al. (1993) identified a longer isoform of mGluR5 (mGluR5B).

The PPXXF motif binds HOMER1 HOMER2 and HOMER3. Interacts with SIAH1 RYR1 RYR2 ITPR1 SHANK1 SHANK3 and GRASP (By similarity).

Belongs to the G-protein coupled receptor 3 family [view classification].