Phospholipase D1

ArtNr	18-272-195146
Hersteller	GENWAY
Menge	0.05 mg
Kategorie	Oncology Metabolism Cholesterol & Lipid Metabolism Antibodies Western Blot Cardiovascular Research Thrombosis & Hemostasis Enzymes Fatty Acid Catabolism Primary Antibodies By Organ Uterine, Ovarian & Cervical Cancer
Typ	Antibody
Applikationen	WB
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-37947F
Similar products	18-272-195146
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Genway ID:	GWB-37947F
Isotype:	IgG
Immunogen:	Synthetic peptide (Human).
Antigen Species:	Human
Positive Control:	Recombinant protein U937 cells
Target:	Phospholipase D1
Localization:	Perinuclear regions: endoplasmic reticulum Golgi apparatus and late endosomes.
Concentration:	0. 5 mg/ml Storage
Preservative:	0. 05% Sodium Azide; Constituents: 1mg/ml BSA PBS
Application Note:	WB: Use at a dilution of 1/100 - 1/2000. Detects a band of approximately 110 kDa (predicted
Molecular Weight:	129 kDa). Due to the low expression levels of this protein it is suggested that the protein is immunoprecipitated before Western blotting. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. Cellular
Localization:	Perinuclear regions: endoplasmic reticulum Golgi apparatus and late endosomes. Activation of Phospholipase D1 results in the generation of second messengers phosphatidic acid and diglycerides and appears to be involved in secretion vesicle trafficking mitosis and meiosis. In leukocytes Phospholipase D1 regulates cytoskeletal-dependent antimicrobial responses such as phagocytosis and oxidant generation. Phospholipase D1 is regulated by GTP-binding proteins (ARF and Rho families) and by protein kinase C.
Function:	Implicated as a critical step in numerous cellular pathways including signal transduction membrane trafficking and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity).
Catalytic Activity:	A phosphatidylcholine + H2O = choline + a phosphatidate.
Enzyme Regulation:	Stimulated by phosphatidylinositol 4 5-bisphosphate and phosphatidylinositol 3 4 5-trisphosphate activated by the phosphokinase C-alpha by the ADP-ribosylation factor-1 (ARF-1) and to a lesser extent by GTP-binding proteins: RHO A RAC-1 and CDC42. Inhibited by oleate.
Subunit:	Interacts with PIP5K1A.
Subcellular Location:	Cytoplasm perinuclear region (By similarity). Endoplasmic reticulum membrane; Lipid-anchor; Cytoplasmic side (By similarity). Golgi apparatus membrane; Lipid-anchor; Cytoplasmic side (By similarity). Late endosome membrane; Lipid-anchor; Cytoplasmic side (By similarity).
Tissue Specificity:	Expressed abundantly in the pancreas and heart and at high levels in brain placenta spleen uterus and small intestine.
Similarity:	Belongs to the phospholipase D family.
Similarity:	Contains 1 PH domain.
Similarity:	Contains 2 PLD phosphodiesterase domains.
Similarity:	Contains 1 PX (phox homology) domain.

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Menge: 0.05 mg

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