ACTH (ready-to-use)

ArtNr	18-272-195514
Hersteller	GENWAY
Menge	6 ml
Kategorie	Antibodies Immunohistochemistry Primary Antibodies
Typ	Antibody
Applikationen	IHC
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-C8279D
Similar products	18-272-195514
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Genway ID:	GWB-C8279D
Isotype:	IgG
Immunogen:	Synthetic human ACTH1-39.
Antigen Species:	Human
Positive Control:	Human pituitary gland normal rabbit serum is included with this product as a negative control
Target:	ACTH
Localization:	Secreted Storage
Preservative:	0. 1% Sodium Azide; Constituents: 1% BSA 0. 01M PBS.
Application Note:	IHC-P: Primary antibody (concentrated format) may be used at a dilution of 1/40 for Biotin based detection systems. Pretreatment is not required. For optimal staining the primary antibody should be incubated 20 to 60 minutes at room temperature. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. Cellular
Localization:	Secreted This anti-ACTH antibody positively stains the corticotroph cells of the pituitary gland and benign and malignant tumors arising from these cells.
Function:	ACTH stimulates the adrenal glands to release cortisol.
Function:	MSH (melanocyte-stimulating hormone) increases the pigmentation of skin by increasing melanin production in melanocytes.
Function:	Beta-endorphin and Met-enkephalin are endogenous opiates.
Tissue Specificity:	ACTH and MSH are produced by the pituitary gland.
Ptm:	Specific enzymatic cleavages at paired basic residues yield the different active peptides.
Ptm:	O-glycosylated; reducing sugar is probably N-acetylgalactosamine.
Polymorphism:	Genetic variation in POMC may influence abdominal body fat distribution [MIM:609830].
Disease:	Defects in POMC may be associated with susceptibility to obesity [MIM:601665].
Disease:	Defects in POMC are the cause of pro-opiomelanocortinin deficiency [MIM:609734]. Affected individuals present early-onset obesity adrenal insufficiency and red hair.
Similarity:	Belongs to the POMC family.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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Menge: 6 ml

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