HCC1

ArtNr	18-272-195687
Hersteller	GENWAY
Menge	0.05 mg
Kategorie	Oncology Antibodies Western Blot Primary Antibodies By Organ Bone Cancer
Typ	Antibody
Applikationen	WB
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-4739F1
Similar products	18-272-195687
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Genway ID:	GWB-4739F1
Isotype:	IgG
Immunogen:	Immunogen was a synthetic peptide which represented a portion of human caper (RNA-binding region [RNP1 RRM] containing 2) encoded within exon 18 (LocusLink ID 9584).
Antigen Species:	Human
Positive Control:	Nuclear extract from HeLa cells
Target:	HCC1
Localization:	Nuclear; concentrated in nuclear speckles. Colocalizes with the core spliceosomal snRNP proteins.
Concentration:	1 mg/ml
Purification Note:	Purified using the peptide immobilized on solid support. Storage
Preservative:	0. 1% Sodium Azide; Constituents: Tris-citrate/phosphate. pH 7 to 8.
Application Note:	WB: Use at a dilution of 1/1000 - 1/10000. Predicted
Molecular Weight:	63 kDa. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. Prepare working dilution immediately before use. Cellular
Localization:	Nuclear; concentrated in nuclear speckles. Colocalizes with the core spliceosomal snRNP proteins. The protein encoded by this gene is an RNA binding protein and possible splicing factor. The encoded protein is found in the nucleus where it colocalizes with core spliceosomal proteins. Studies of a mouse protein with high sequence similarity to this protein suggest that this protein may act as a transcriptional coactivator for JUN/AP1 and estrogen receptors. Multiple transcript variants encoding several different isoforms have been found for this gene.
Function:	Has weak activities on human monocytes and acts via receptors that also recognize MIP-1 alpha. It induced intracellular Ca(2+) changes and enzyme release but no chemotaxis at concentrations of 100-1 000 nM and was inactive on T-lymphocytes neutrophils and eosinophil leukocytes. Enhances the proliferation of CD34 myeloid progenitor cells. The processed form HCC-1(9-74) is a chemotactic factor that attracts monocytes eosinophils and T-cells and is a ligand for CCR1 CCR3 and CCR5.
Subcellular Location:	Secreted.
Tissue Specificity:	Expressed constitutively in several normal tissues: spleen liver skeletal and heart muscle gut and bone marrow present at high concentrations (1-80 nM) in plasma.
Ptm:	The N-terminal processed forms HCC-1(3-74) HCC-1(4-74) and HCC-1(9-74) are produced in small amounts by proteolytic cleavage after secretion in blood.
Ptm:	HCC-1(1-74) but not HCC-1(3-74) and HCC-1(4-74) is partially O-glycosylated; the O-linked glycan consists of one Gal-GalNAc disaccharide further modified by two N-acetylneuraminic acids.
Similarity:	Belongs to the intercrine beta (chemokine CC) family.

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