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Claudin 1 (ready-to-use)

Claudin 1 (ready-to-use)

ArtNr	18-272-196242
Hersteller	GENWAY
Menge	7 ml
Kategorie	Oncology Antibodies Immunohistochemistry Primary Antibodies By Organ Breast Cancer
Typ	Antibody
Applikationen	IHC
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-18FD82
Similar products	18-272-196242
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Genway ID:	GWB-18FD82
Isotype:	IgG
Immunogen:	Synthetic peptide (Human) (C terminal).
Antigen Species:	Human
Positive Control:	Skin or breast carcinoma cells
Target:	Claudin 1
Localization:	Cell Membrane
Concentration:	ready-to-use Storage
Buffer:	Phosphate-buffered saline pH 7. 2 containing 1%BSA and 0. 09% sodium azide
Application Note:	IHC-P: Ready to use. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate buffer pH 6. 0 for 10 min followed by cooling at RT for 20 min. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. Cellular
Localization:	Cell Membrane Claudin 1-8 proteins are a family of transmembrane proteins associated with tight junctions. Tight junctions are specialized regions of cell to cell contact; made up of network of strands to act as a molecular gasket for preventing the leakage of ions water etc. between cells. They are abundant in luminal epithelial sheets where they maintain epithelial cell polarity. Different tissues exhibit different Claudin composition.
Function:	Plays a major role in tight junction-specific obliteration of the intercellular space through calcium-independent cell-adhesion activity (By similarity). Acts as a co-receptor for HCV entry into hepatic cells.
Subunit:	Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN3 but not CLDN2 homopolymers. Directly interacts with TJP1/ZO-1 TJP2/ZO-2 and TJP3/ZO-3. Interacts with MPDZ and INADL (By similarity). May interact with HCV E1 and E2 proteins.
Subcellular Location:	Cell junction tight junction (By similarity). Cell membrane; Multi-pass membrane protein (By similarity).
Tissue Specificity:	Strongly expressed in liver and kidney. Expressed in heart brain spleen lung and testis.
Disease:	Defects in CLDN1 are the cause of ichthyosis-sclerosing cholangitis neonatal syndrome (NISCH) [MIM:607626]; also called ichthyosis with leukocyte vacuoles alopecia and sclerosing cholangitis (ILVASC). NISCH is a rare autosomal recessive complex ichthyosis syndrome characterized by scalp hypotrichosis scarring alopecia vulgar type ichthyosis and sclerosing cholangitis.
Similarity:	Belongs to the claudin family.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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Menge: 7 ml

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