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beta Synuclein (ready-to-use)

beta Synuclein (ready-to-use)

ArtNr	18-272-196448
Hersteller	GENWAY
Menge	7 ml
Kategorie	Oncology Antibodies Immunohistochemistry Primary Antibodies By Organ Lung Cancer
Typ	Antibody
Applikationen	IHC
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-96DD67
Similar products	18-272-196448
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Genway ID:	GWB-96DD67
Isotype:	IgG
Immunogen:	Synthetic peptide (unfortunately the amino acid sequence is considered to be commercially sensitive) (Human) (C terminal).
Antigen Species:	Human
Specificity:	This antibody is specific for beta synuclein and does not cross react withalpha or gamma synuclein. Stains neuronal cytosol and presynaptic terminals.
Positive Control:	Brain.
Target:	beta Synuclein
Localization:	Cytoplasmic Storage
Buffer:	PBS pH 7. 4 containing 1%BSA and 0. 1% sodium azide
Application Note:	IHC-P: Ready to use for 10 minutes at room temperature. No special pretreatment is required for the immunohistochemical staining of formalin/paraffin tissues. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. Cellular
Localization:	Cytoplasmic Synucleins are small soluble proteins expressed primarily in neural tissue and in certain tumors. The family includes three known proteins: alpha synuclein beta synuclein and gamma synuclein. The alpha and beta synuclein proteins are found primarily in brain tissue where they are seen mainly in presynaptic terminals.
Function:	Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6 hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.
Subcellular Location:	Cytoplasm.
Tissue Specificity:	Expressed predominantly in brain; concentrated in presynaptic nerve terminals.
Ptm:	Phosphorylated. Phosphorylation by G-protein coupled receptor kinases (GRK) is more efficient than phosphorylation by CK1 CK2 and CaM-kinase II.
Disease:	Brain iron accumulation type 1 (NBIA1 also called Hallervorden-Spatz syndrome) a rare neuroaxonal dystrophy is histologically characterized by axonal spheroids iron deposition Lewy body (LB)-like intraneuronal inclusions glial inclusions and neurofibrillary tangles. SNCB is found in spheroids but not in inclusions.
Similarity:	Belongs to the synuclein family.

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Menge: 7 ml

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