AMPK alpha 1

IgG

Human

1. 0 mg/ml Storage

For IP: Use at a concentration of 2 - 8 µ g/mg of lysate. For WB: Use at a dilution of 1:500 - 1:5 000. Predicted

63kD Protein kinases are enzymes that transfer a phosphate group from a phosphate donor generally the g phosphate of ATP onto an acceptor amino acid in a substrate protein. By this basic mechanism protein kinases mediate most of the signal transduction in eukaryotic cells regulating cellular metabolism transcription cell cycle progression cytoskeletal rearrangement and cell movement apoptosis and differentiation. With more than 500 gene products the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains.

ATP + a protein = ADP + a phosphoprotein. Cofactor: Magnesium.

Heterotrimer of an alpha catalytic subunit a beta and a gamma non-catalytic subunits. Interacts with FNIP1 and FNIP2.

Contains 1 protein kinase domain.