Phospholipase C1

ArtNr	18-272-198308
Hersteller	GENWAY
Menge	0.5 ml
Kategorie	Oncology Antibodies Immunoprecipitation Western Blot Cardiovascular Research Thrombosis & Hemostasis Primary Antibodies By Organ Colorectal Cancer
Typ	Antibody
Applikationen	WB, IP
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-33F05D
Similar products	18-272-198308
Lieferbar
Genway ID:	GWB-33F05D
Immunogen:	A synthetic peptide derived from the C-terminus of Bovine PLCgamma1 protein
Antigen Species:	Bovine
Positive Control:	Jurkat and A431 Cells
Target:	Phospholipase C1
Localization:	Cytoplasmic
Concentration:	1 mg/ml Storage
Buffer:	10mM Phosphate-buffered saline containing 0. 2% BSA and 0. 1% sodium azide
Application Note:	For IP: Use at a dilution of 1:1 000. For WB: Use at a dilution of 1:1 000. Not tested in other applications. Optimal dilutions/concentrations should be determined by the researcher. Cellular
Localization:	Cytoplasmic Phospholipase C is a key enzyme in many signal transduction pathways stimulated by cytokines hormones growth factors. It hydrolyses phosphatidylinositol-4 5 -diphosphate into inositol1 4 5 -triphosphate (IP3) and 1 2-diacylglycerol (DAG).
Function:	PLC-gamma is a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase.
Catalytic Activity:	1-phosphatidyl-1D-myo-inositol 4 5-bisphosphate + H2O = 1D-myo-inositol 1 4 5-trisphosphate + diacylglycerol. Cofactor: Calcium.
Subunit:	Interacts with CENTG1 via its SH3 domain (By similarity). Interacts with phosphorylated LAT upon TCR activation. Interacts with the Pro-rich domain of TNK1 via its SH3 domain. Associates with BLNK VAV1 GRB2 and NCK1 in a B-cell antigen receptor-dependent fashion. Interacts with CBLB in activated T-cells; which inhibits phosphorylation. Interacts with SHB. Interacts via its SH3 domain with the Arg/Gly-rich-flanked Pro-rich domains of KHDRBS1/SAM68. This interaction is selectively regulated by arginine methylation of KHDRBS1/SAM68. Interacts with INPP5D/SHIP1 and MIST (By similarity). Interacts with RALGPS1. Interacts (via SH3 domain) with HEV ORF3 protein.
Domain:	The SH3 domain mediates interaction with MIST (By similarity). The SH3 domain also mediates interaction with RALGPS1.
Ptm:	The receptor-mediated activation of PLC-gamma-1 and PLC-gamma-2 involves their phosphorylation by tyrosine kinases in response to ligation of a variety of growth factor receptors and immune system receptors.
Ptm:	Ubiquitinated by CBLB in activated T-cells (By similarity).
Similarity:	Contains 1 C2 domain.
Similarity:	Contains 1 EF-hand domain.
Similarity:	Contains 2 PH domains.
Similarity:	Contains 1 PI-PLC X-box domain.
Similarity:	Contains 1 PI-PLC Y-box domain.
Similarity:	Contains 2 SH2 domains.
Similarity:	Contains 1 SH3 domain.

Hinweis: Die dargestellten Informationen und Dokumente (Bedienungsanleitung, Produktdatenblatt, Sicherheitsdatenblatt und Analysezertifikat) entsprechen unserem letzten Update und sollten lediglich der Orientierung dienen. Wir übernehmen keine Garantie für die Aktualität. Für spezifische Anforderungen bitten wir Sie, uns eine Anfrage zu stellen.

Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Arbeitsanleitung (Data Sheet) anfordern

Produkt-Datenblatt anfordern

Sicherheitsdatenblatt anfordern

Einfache Bestellung Periodische Bestellung

Menge: 0.5 ml

lieferbar

Lieferung vsl. bis 11.09.2025

Express-Lieferung: 3 Tage sparen

Vergleichen

Auf den Wunschzettel

Angebot anfordern