S100 protein

GWB-A1E48E

Bovine

Brain or skin

From polyclonal serum. Storage

For IHC-Fr: Use at a dilution of 1:10 - 1:40. For IHC-P: Use at a dilution of 1:10 - 1:40. Not tested in other applications. Optimal dilutions/concentrations should be determined by the researcher. S100 belongs to the family of calcium binding proteins such as calmodulin and troponin C. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. S100A is composed of an alpha and beta chain whereas S100B is composed of two beta chains. S100 protein may function in stimulation of Ca2+ induced Ca2+ release inhibition of microtubule assembly and inhibition of protein kinase C mediated phosphorylation. Reduced expression of this protein has been implicated in cardiomyopathies. Immunoreactive S100 protein localizes in the cytoplasm and nuclei of astrocytes Schwann\' s cells ependymomas and astrogliomas. Ganglion cells do not stain for S100 protein. S100 can be detected in almost all benign naevi and malignant melanocytic tumours of the skin and in Langerhans cells in the skin.

Dimer of either two alpha chains or two beta chains or one alpha and one beta chain. The S100B dimer binds two molecules of STK38 (By similarity). The S100B dimer interacts with two molecules of CAPZA1.

Although predominant among the water-soluble brain proteins S100 is also found in a variety of other tissues.

Belongs to the S-101 family.