INTERFERON GAMMA

GWB-152BEE

Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma in addition to having antiviral activity has important immunoregulatory functions. It is a potent activator of macrophages it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.

Secreted.

Belongs to the type II (or gamma) interferon family. Summary: an immune molecule produced by T lymphocytes in response to mitogens or antigens [RGD]. [1] Lee J. Kim S. J. Son T. G. Chan S. L. and Mattson M. P. et al. Interferon-gamma is up-regulated in the hippocampus in response to intermittent fasting and protects hippocampal neurons against excitotoxicity[2] Maher F. O. Clarke R. M. Kelly A. Nally R. E. and Lynch M. A. et al. Interaction between interferon gamma and insulin-like growth factor-1 in hippocampus impacts on the ability of rats to sustain long-term potentiation[3] Mirza S. Muthana M. Fairburn B. Slack L. K. Hopkinson K. and Pockley A. G. The stress protein gp96 is not an activator of resting rat bone marrow-derived dendritic cells but is a costimulator and activator of CD3+ T cells[4] Emery B. Butzkueven H. Snell C. Binder M. and Kilpatrick T. J. et al. Oligodendrocytes exhibit selective expression of suppressor of cytokine signaling genes and signal transducer and activator of transcription 1 independent inhibition of interferon-gamma-induced toxicity in response to leukemia inhibitory factor[5] Obara H. Nagasaki K. Hsieh C. L. Ogura Y. Esquivel C. O. Martinez O. M. and Krams S. M. IFN-gamma produced by NK cells that infiltrate liver allografts early after transplantation links the innate and adaptive immune responses[6] Dijkema R. van der Meide P. H. Pouwels P. H. Caspers M. Dubbeld M. Schellekens H. Cloning and expression of the chromosomal immune interferon gene of the rat. [7] Dijkema R. der Meide P. H. Dubbeld M. Caspers M. Wubben J. Schellekens H. Cloning expression and purification of rat IFN-gamma. [8] Widegren B. Visse E. Sjogren H. O. Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases.