C-C chemokine receptor type 1

2nd extracellular domain of human. Synthetic peptide - KLH conjugated.

Membrane; multi-pass membrane protein.

Belongs to the G-protein coupled receptor 1 family [view classification]. Summary: This protein is a member of the beta chemokine receptor family which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha) regulated on activation normal T expressed and secreted protein (RANTES) monocyte chemoattractant protein 3 (MCP-3) and myeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response and susceptibility to virus and parasite. This protein and other chemokine receptor genes including CCR2 CCRL2 CCR3 CCR5 and CCXCR1 are found to form a gene cluster on chromosome 3p. [1] Kim I. S. Jang S. W. Sung H. J. Lee J. S. and Ko J. et al. Differential CCR1-mediated chemotaxis signaling induced by human CC chemokine HCC-4/CCL16 in HOS cells[2] Hwang J. Son K. N. Kim C. W. Ko J. Na D. S. Kwon B. S. Gho Y. S. and Kim J. Human CC chemokine CCL23 a ligand for CCR1 induces endothelial cell migration and promotes angiogenesis[3] Wieser F. Dogan S. Klingel K. Diedrich K. Taylor R. N. and Hornung D. Expression and regulation of CCR1 in peritoneal macrophages from women with and without endometriosis[4] de Mendonca F. L. da Fonseca P. C. Phillips R. M. Saldanha J. W. Williams T. J. and Pease J. E. Site-directed mutagenesis of CC chemokine receptor 1 reveals the mechanism of action of UCB 35625 a small molecule chemokine receptor antagonist[5] Lee S. M. Shin H. Jang S. W. Shim J. J. Song I. S. Son K. N. Hwang J. Shin Y. H. Kim H. H. Lee C. K. Ko J. Na D. S. Kwon B. S. et al. PLP2/A4 interacts with CCR1 and stimulates migration of CCR1-expressing HOS cells[6] Neote K. Digregorio D. Mak J. Y. Horuk R. Schall T. J. Molecular cloning functional expression and signaling characteristics of a C-C chemokine receptor. [7] Gao J. -L. Kuhns D. Tiffany H. L. McDermott D. Li X. Francke U. Murphy P. M. Structure and functional expression of the human macrophage inflammatory protein 1 alpha/RANTES receptor. [8] Nomura H. Nielsen B. W. Matsushima K. Molecular cloning of cDNAs encoding a LD78 receptor and putative leukocyte chemotactic peptide receptors. [9] Strausberg R. L. Feingold E. A. Grouse L. H. Derge J. G. Klausner R. D. Collins F. S. Wagner L. Shenmen C. M. Schuler G. D. Altschul S. F. et al. Generation and initial analysis of more than 15 000 full-length human and mouse cDNA sequences.