C-C chemokine receptor type 9

C-terminal domain of human. Synthetic peptide - KLH conjugated.
Uses: IHC (2 - 4 ug/ml) (Optimal dilution to be determined by the researcher)

Membrane; multi-pass membrane protein.

Belongs to the G-protein coupled receptor 1 family [view classification]. Summary: The protein encoded by this gene is a member of the beta chemokine receptor family. It is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are key regulators of the thymocytes migration and maturation in normal and inflammation conditions. The specific ligand of this receptor is CCL25. It has been found that this gene is differentially expressed by T lymphocytes of small intestine and colon suggested a role in the thymocytes recruitment and development that may permit functional specialization of immune responses in different segment of the gastrointestinal tract. This protein is mapped to the chemokine receptor gene cluster region. Two alternatively spliced transcript variants have been described. [1] Sen Y. Yongyi B. Yuling H. Luokun X. Li H. Jie X. Tao D. Gang Z. Junyan L. Chunsong H. Zhang X. Youxin J. Feili G. et al. V alpha 24-invariant NKT cells from patients with allergic asthma express CCR9 at high frequency and induce Th2 bias of CD3+ T cells upon CD226 engagement[2] Babu S. Blauvelt C. P. Kumaraswami V. and Nutman T. B. et al. Chemokine receptors of T cells and of B cells in lymphatic filarial infection: a role for CCR9 in pathogenesis[3] Singh S. Singh U. P. Stiles J. K. Grizzle W. E. and Lillard J. W. Jr. Expression and functional role of CCR9 in prostate cancer cell migration and invasion[4] Qiuping Z. Qun L. Chunsong H. Xiaolian Z. Baojun H. Mingzhen Y. Chengming L. Jinshen H. Qingping G. Kejian Z. et al. Selectively increased expression and functions of chemokine receptor CCR9 on CD4+ T cells from patients with T-cell lineage acute lymphocytic leukemia[5] Papadakis K. A. Landers C. Prehn J. Kouroumalis E. A. Moreno S. T. Gutierrez-Ramos J. C. Hodge M. R. and Targan S. R. CC chemokine receptor 9 expression defines a subset of peripheral blood lymphocytes with mucosal T cell phenotype and Th1 or T-regulatory 1 cytokine profile[6] Lautens L. L. Tiffany H. L. Gao J. -L. Modi W. Murphy P. M. Bonner T. I. Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases. [7] Warren C. N. Aronstam R. S. Sharma S. V. cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www. cdna. org). [8] Zaballos A. Gutierrez J. Varona R. Ardavin C. Marquez G. Identification of the orphan chemokine receptor GPR-9-6 as CCR9 the receptor for the chemokine TECK.