Alpha-1D adrenergic receptor

GWB-5A48A0

This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium.

Belongs to the G-protein coupled receptor 1 family [view classification]. Summary: Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A -1B and -1D all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This protein is alpha-1D-adrenergic receptor. Similar to alpha-1B-adrenergic receptor gene this gene comprises 2 exons and a single intron that interrupts the coding region. [1] Chen Z. Hague C. Hall R. A. and Minneman K. P. et al. Syntrophins regulate alpha1D-adrenergic receptors through a PDZ domain-mediated interaction[2] Sigala S. Dellabella M. Milanese G. Fornari S. Faccoli S. Palazzolo F. Peroni A. Mirabella G. Cunico S. C. Spano P. and et al. Evidence for the presence of alpha1 adrenoceptor subtypes in the human ureter[3] Gonzalez-Cabrera P. J. Shi T. Yun J. McCune D. F. Rorabaugh B. R. and Perez D. M. Differential regulation of the cell cycle by alpha1-adrenergic receptor subtypes[4] Hague C. Uberti M. A. Chen Z. Hall R. A. and Minneman K. P. et al. Cell surface expression of alpha1D-adrenergic receptors is controlled by heterodimerization with alpha1B-adrenergic receptors[5] Shibata K. Katsuma S. Koshimizu T. Shinoura H. Hirasawa A. Tanoue A. and Tsujimoto G. alpha 1-Adrenergic receptor subtypes differentially control the cell cycle of transfected CHO cells through a cAMP-dependent mechanism involving p27Kip1[6] Bruno J. F. Whittaker J. Song J. Berelowitz M. Molecular cloning and sequencing of a cDNA encoding a human alpha 1A adrenergic receptor. [7] Forray C. Bard J. A. Wetzel J. M. Chiu G. Shapiro E. Tang R. Lepor H. Hartig P. R. Weinshank R. L. Branchek T. A. et al. The alpha 1-adrenergic receptor that mediates smooth muscle contraction in human prostate has the pharmacological properties of the cloned human alpha 1c subtype. [8] Schwinn D. A. Johnston G. I. Page S. O. Mosley M. J. Wilson K. H. Worman N. P. Campbell S. Fidock M. D. Furness L. M. Parry-Smith D. J. et al. Cloning and pharmacological characterization of human alpha-1 adrenergic receptors: sequence corrections and direct comparison with other species homologues. [9] Weinberg D. H. Trivedi P. Tan C. P. Mitra S. Perkins-Barrow A. Borkowski D. Strader C. D. Bayne M. Cloning expression and characterization of human alpha adrenergic receptors alpha 1a alpha 1b and alpha 1c. [10] Esbenshade T. A. Hirasawa A. Tsujimoto G. Tanaka T. Yano J. Minneman K. P. Murphy T. J. Cloning of the human alpha 1d-adrenergic receptor and inducible expression of three human subtypes in SK-N-MC cells.