Muscarinic acetylcholine receptor M2

GWB-A4BF2D

The muscarinic acetylcholine receptor mediates various cellular responses including inhibition of adenylate cyclase breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition.

Belongs to the G-protein coupled receptor 1 family [view classification]. Summary: The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine to these receptors and includes cellular responses such as adenylate cyclase inhibition phosphoinositide degeneration and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 2 is involved in mediation of bradycardia and a decrease in cardiac contractility. Multiple alternatively spliced transcript variants have been described for this gene. [1] Goin J. C. and Nathanson N. M. et al. Quantitative analysis of muscarinic acetylcholine receptor homo- and heterodimerization in live cells: regulation of receptor down-regulation by heterodimerization[2] Mou L. Gates A. Mosser V. A. Tobin A. and Jackson D. A. et al. Transient hypoxia induces sequestration of M1 and M2 muscarinic acetylcholine receptors[3] Zuchner T. Schliebs R. and Perez-Polo J. R. et al. Down-regulation of muscarinic acetylcholine receptor M2 adversely affects the expression of Alzheimer\' s disease-relevant genes and proteins[4] Luo X. Kranzler H. R. Zuo L. Wang S. Blumberg H. P. and Gelernter J. CHRM2 gene predisposes to alcohol dependence drug dependence and affective disorders: results from an extended case-control structured association study[5] Krejci A. Bruce A. W. Dolezal V. Tucek S. and Buckley N. J. et al. Multiple promoters drive tissue-specific expression of the human M muscarinic acetylcholine receptor gene[6] Bonner T. I. Buckley N. J. Young A. C. Brann M. R. Identification of a family of muscarinic acetylcholine receptor genes. [7] Peralta E. G. Ashkenazi A. Winslow J. W. Smith D. H. Ramachandran J. Capon D. J. Distinct primary structures ligand-binding properties and tissue-specific expression of four human muscarinic acetylcholine receptors. [8] Puhl H. L. III Ikeda S. R. Aronstam R. S. cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www. cdna. org). [9] Kitano T. Kobayakawa H. Saitou N. Silver project.