Muscarinic acetylcholine receptor M4

GWB-BB6B7E

The muscarinic acetylcholine receptor mediates various cellular responses including inhibition of adenylate cyclase breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is inhibition of adenylate cyclase.

Belongs to the G-protein coupled receptor 1 family [view classification]. Summary: The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine to these receptors and includes cellular responses such as adenylate cyclase inhibition phosphoinositide degeneration and postassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The clinical implications of this receptor are unknown; however mouse studies link its function to adenylyl cyclase inhibition. [1] Mulugeta E. Karlsson E. Islam A. Kalaria R. Mangat H. Winblad B. and Adem A. Loss of muscarinic M4 receptors in hippocampus of Alzheimer patients[2] Dean B. McLeod M. Keriakous D. McKenzie J. and Scarr E. et al. Decreased muscarinic1 receptors in the dorsolateral prefrontal cortex of subjects with schizophrenia[3] von der Kammer H. Mayhaus M. Albrecht C. Enderich J. Wegner M. and Nitsch R. M. Muscarinic acetylcholine receptors activate expression of the EGR gene family of transcription factors[4] van Koppen C. J. Lenz W. and Nathanson N. M. et al. Isolation sequence and functional expression of the mouse m4 muscarinic acetylcholine receptor gene[5] Grewal R. P. Martinez M. Hoehe M. Bonner T. I. Gershon E. S. and Detera-Wadleigh S. Genetic linkage mapping of the m4 human muscarinic receptor (CHRM4)[6] Bonner T. I. Buckley N. J. Young A. C. Brann M. R. Identification of a family of muscarinic acetylcholine receptor genes. [7] Bonner T. I. Young A. C. Brann M. R. Buckley N. J. Cloning and expression of the human and rat m5 muscarinic acetylcholine receptor genes. [8] Peralta E. G. Ashkenazi A. Winslow J. W. Smith D. H. Ramachandran J. Capon D. J. Distinct primary structures ligand-binding properties and tissue-specific expression of four human muscarinic acetylcholine receptors. [9] Puhl H. L. III Ikeda S. R. Aronstam R. S. cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www. cdna. org).