C-C chemokine receptor type 8

GWB-F64CE2

Receptor for the chemokine SCYA1/I-309. May regulate monocyte chemotaxis and thymic cell line apoptosis. Alternative coreceptor with CD4 for HIV-1 infection.

Belongs to the G-protein coupled receptor 1 family [view classification]. Summary: This protein is a member of the beta chemokine receptor family which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are important for the migration of various cell types into the inflammatory sites. This receptor protein preferentially expresses in the thymus. I-309 thymus activation-regulated cytokine (TARC) and macrophage inflammatory protein-1 beta (MIP-1 beta) have been identified as ligands of this receptor. Studies of this receptor and its ligands suggested its role in regulation of monocyte chemotaxis and thymic cell apoptosis. More specifically this receptor may contribute to the proper positioning of activated T cells within the antigenic challenge sites and specialized areas of lymphoid tissues. This protein is located at the chemokine receptor gene cluster region. [1] Gombert M. Dieu-Nosjean M. C. Winterberg F. Bunemann E. Kubitza R. C. Da Cunha L. Haahtela A. Lehtimaki S. Muller A. et al. CCL1-CCR8 interactions: an axis mediating the recruitment of T cells and Langerhans-type dendritic cells to sites of atopic skin inflammation[2] Haque N. S. Fallon J. T. Pan J. J. Taubman M. B. and Harpel P. C. et al. Chemokine receptor-8 (CCR8) mediates human vascular smooth muscle cell chemotaxis and metalloproteinase-2 secretion[3] Gilchrest H. Cheewatrakoolpong B. Billah M. Egan R. W. Anthes J. C. and Greenfeder S. Human cord blood-derived mast cells synthesize and release I-309 in response to IgE[4] Asojo O. A. Boulegue C. Hoover D. M. Lu W. and Lubkowski J. et al. Structures of thymus and activation-regulated chemokine (TARC)[5] DeVries M. E. Cao H. Wang J. Xu L. Kelvin A. A. Ran L. Chau L. A. Madrenas J. Hegele R. A. and Kelvin D. J. Genomic organization and evolution of the CX3CR1/CCR8 chemokine receptor locus[6] Zaballos A. Varona R. Gutierrez J. Lind P. Marquez G. Molecular cloning and RNA expression of two new human chemokine receptor-like genes. [7] Samson M. Stordeur P. Labbe O. Soularue P. Vassart G. Parmentier M. Molecular cloning and chromosomal mapping of a novel human gene ChemR1 expressed in T lymphocytes and polymorphonuclear cells and encoding a putative chemokine receptor. [8] Tiffany H. L. Lautens L. L. Gao J. -L. Pease J. Locati M. Combadiere C. Modi W. Bonner T. I. Murphy P. M. Identification of CCR8: a human monocyte and thymus receptor for the CC chemokine I-309. [9] Goya I. Gutierrez J. Varona R. Kremer L. Zaballos A. Marquez G. Identification of CCR8 as the specific receptor for the human beta-chemokine I-309: cloning and molecular characterization of murine CCR8 as the receptor for TCA-3. [10] Nakajima T. Yoshida R. Harada S. Molecular cloning of a human novel C-C chemokine receptor.