Glucagon receptor

N-terminal extracellular domain of human. Synthetic peptide - KLH conjugated.
Uses: IHC (8 ug/ml) (Optimal dilution to be determined by the researcher)

Membrane; multi-pass membrane protein.

Belongs to the G-protein coupled receptor 2 family [view classification]. Summary: The physiologic effects of glucagon (GCG; MIM 138030) are mediated through the glucagon receptor a member of the superfamily of receptors characterized by a 7-transmembrane domain structure and by their coupling via GTP-binding proteins (G proteins) to adenyl cyclase. [supplied by OMIM]. [1] Runge S. Gram C. Brauner-Osborne H. Madsen K. Knudsen L. B. and Wulff B. S. Three distinct epitopes on the extracellular face of the glucagon receptor determine specificity for the glucagon amino terminus[2] Shiota D. Kasamatsu T. Dib S. A. Chacra A. R. and Moises R. S. et al. Role of the Gly40Ser mutation in the glucagon receptor gene in Brazilian patients with type 2 diabetes mellitus[3] Strazzullo P. Iacone R. Siani A. Barba G. Russo O. Russo P. Barbato A. D\' Elia L. Farinaro E. and Cappuccio F. P. Altered renal sodium handling and hypertension in men carrying the glucagon receptor gene (Gly40Ser) variant[4] Yamato E. Ikegami H. Takekawa K. Fujisawa T. Nakagawa Y. Hamada Y. Ueda H. and Ogihara T. Tissue-specific and glucose-dependent expression of receptor genes for glucagon and glucagon-like peptide-1 (GLP-1)[5] Chambers S. M. and Morris B. J. et al. Glucagon receptor gene mutation in essential hypertension[6] Macneil D. J. Occi J. L. Hey P. J. Strader C. D. Graziano M. P. Cloning and expression of a human glucagon receptor. [7] Lok S. Kuijper J. L. Jelinek L. J. Kramer J. M. Whitmore T. E. Sprecher C. A. Mathewes S. Grant F. J. Biggs S. H. Rosenberg G. B. et al. The human glucagon receptor encoding gene: structure cDNA sequence and chromosomal localization. [8] Menzel S. Stoffel M. Espinosa R. III Fernald A. A. Le Beau M. M. Bell G. I. Localization of the glucagon receptor gene to human chromosome band 17q25. [9] Fujisawa T. Ikegami H. Yamato E. Takekawa K. Nakagawa Y. Hamada Y. Ueda H. Fukuda M. Ogihara T. A mutation in the glucagon receptor gene (Gly40Ser): heterogeneity in the association with diabetes mellitus.