Seven transmembrane helix receptor

N-terminal extracellular domain of human. Synthetic peptide - KLH conjugated.
Uses: WB IHC (Optimal dilution to be determined by the researcher) Summary: Gene type: protein codingGene name: SMOGene description: smoothened homolog (Drosophila)RefSeq status: ProvisionalOrganism: Homo sapiens [1] Sicklick J. K. Li Y. X. Jayaraman A. Kannangai R. Qi Y. Vivekanandan P. Ludlow J. W. Owzar K. Chen W. Torbenson M. S. and et al. Dysregulation of the Hedgehog pathway in human hepatocarcinogenesis[2] Chen W. Ren X. R. Nelson C. D. Barak L. S. Chen J. K. Beachy P. A. de Sauvage F. and Lefkowitz R. J. Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2[3] Grachtchouk V. Grachtchouk M. Lowe L. Johnson T. Wei L. Wang A. de Sauvage F. and Dlugosz A. A. The magnitude of hedgehog signaling activity defines skin tumor phenotype[4] Scherer S. W. Cheung J. MacDonald J. R. Osborne L. R. Nakabayashi K. Herbrick J. A. Carson A. R. Parker-Katiraee L. et al. Human chromosome 7: DNA sequence and biology[5] Couve-Privat S. Bouadjar B. Avril M. F. Sarasin A. and Daya-Grosjean L. Significantly high levels of ultraviolet-specific mutations in the smoothened gene in basal cell carcinomas from DNA repair-deficient xeroderma pigmentosum patients[6] Suwa M. Sato T. Okouchi I. Arita M. Futami K. Matsumoto S. Tsutsumi S. Aburatani H. Asai K. Akiyama Y. et al. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.