Rabbit anti D2s Dopamine Rec.

GWB-4AB6E0

D2s (Ac-239-246-Cys247) covalently attached to a carrier protein.

Specific for Dopamine D2s Receptor (a. a. 239-246). This antisera has been characterized by immunocytochemical Western immunoblot and ELISA techniques. Cross-re

Polyclonal Antibodies for Neuroscience

Not applicable. Applications Notes : Suitable for immunocytochemical and Western blot detection of the D2s dopamine receptor. This antiserum has been found to stain specific cells in various regions of PLP fixed rat brain sections at 1:500 dilution. This includes Medial septum Nucleus accumbens Dentate gyrus Globus pallidus Medial forebrain bundle Cortex regions 1-3 Substantia Nigra reticulata and the Ventral tegmental area. Western immunoblots using whole rat brain homogenate resulted in a single band being detected at ~48kD at 1:800 dilution. Rabbit anti Dopamine D2s Rec. . Rabbit Antibody to Dopamine D2s Receptor (a. a. 239-246)

Interacts with GPRASP1 PPP1R9B and CLIC6 (By similarity). Interacts with CADPS and CADPS2.

Genetic variations in DRD2 may determine the genetic susceptibility to alcoholism [MIM:103780]. Genetic variations in DRD2 might be a protective factor against the development of withdrawal symptoms but might also be a risk factor in a highly burdened subgroup of alcoholics with a paternal and grandpaternal history of alcoholism and might contribute to suicide risk in alcoholics.

Defects in DRD2 are associated with myoclonus dystonia (MD) [MIM:159900]; also known as myoclonic dystonia alcohol-responsive dystonia and dystonia-11 (DYT11). MD is a movement disorder characterized by involuntary lightning jerks and dystonic movements and postures alleviated by alcohol. Inheritance is autosomal dominant. The age of onset pattern of body involvement presence of myoclonus and response to alcohol are all variable.