Rabbit A&#039, M2 Muscarinic Rec.

GWB-D71644

Peptide analogue of the carboxyl terminal of the Muscarinic M2 receptor covalently attached to a carrier protein.

Specific for Muscarinic M2 Receptor (carboxyl terminal) (a. a. 457-466). This antisera has been characterized by Western blotting ELISA and cell staining techniques. Cross-re

Polyclonal Antibodies for Neuroscience

Not applicable. Applications Notes : Suitable for immunocytochemical and western immunoblotting detection of the receptor. Has been found to stain PLP fixed rat brain sections known to express the muscarinic M2 receptor using ABC techniques at a dilution of 1:5 000. Western immunoblots using whole rat brain homogenate has been successful at a dilution of 1:1 000. Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded. Rabbit A\' M2 Muscarinic Rec. . Rabbit Antibody to Muscarinic M2 Receptor (carboxyl terminal) (amino acids 457-466)

Cell membrane; Multi-pass membrane protein. Cell junction synapse postsynaptic cell membrane; Multi-pass membrane protein.

Genetic variations in CHRM2 can influence susceptibility to major depressive disorder (MDD) [MIM:608516]. MDD is one of the most common psychiatric disorders. MDD is a complex trait characterized by one or more major depressive episodes without a history of manic mixed or hypomanic episodes. A major depressive episode is characterized by at least 2 weeks during which there is a new onset or clear worsening of either depressed mood or loss of interest or pleasure in nearly all activities. Four additional symptoms must also be present including changes in appetite weight sleep and psychomotor activity; decreased energy; feelings of worthlessness or guilt; difficulty thinking concentrating or making decisions; or recurrent thoughts of death or suicidal ideation plans or attempts. The episode must be accompanied by distress or impairment in social occupational or other important areas of functioning.