Rabbit anti NPR-Bi

Catalytic
ArtNr	18-511-244578
Hersteller	GENWAY
Menge	0.02 ml
Kategorie	Antibodies Immunohistochemistry Western Blot Cardiovascular Research Hypertension Primary Antibodies
Typ	Antibody
Applikationen	WB, IHC
Specific against	other
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-AD8B4D
Similar products	18-511-244578
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Genway ID:	GWB-AD8B4D
Host Animal:	Rabbit
Immunogen:	Synthetic human NPR-Bi isoform a BTG conjugated
Specificity:	Natriuretic Peptide Receptor Bi (NPR-Bi)
Specificity:	Synthetic human NPR-Bi
Type of Product:	Polyclonal Antibodies to Cardiac Markers
Concentration:	Not determined.
Buffer:	Not applicable. Applications Notes : Suitable for use in Western blot (1:100) Immunohistochemistry (frozen sections 1:100) and immunoaffinity purification. Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded. Rabbit anti NPR-Bi. Rabbit Antibody to Human Natriuretic Peptide Receptor Bi (NPR-Bi)
Function:	Receptor for atrial natriuretic peptide (ANP) brain natriuretic peptide (BNP) and C-type natriuretic peptide (CNP). Has guanylate cyclase activity on binding of ligand. The activation order seems to be CNP & gt; BNP & gt; ANP.
Activity:	GTP = 3\' 5\' -cyclic GMP + diphosphate.
Subcellular Location:	Membrane; Single-pass type I membrane protein.
Ptm:	Phosphorylation of the protein kinase-like domain is required for full activation by CNP (By similarity).
Disease:	Defects in NPR2 are the cause of acromesomelic dysplasia Maroteaux type (AMDM) [MIM:602875]. Acromesomelic chondrodysplasias are rare hereditary skeletal disorders characterized by short stature very short limbs and hand/foot malformations. The severity of limb abnormalities increases from proximal to distal with profoundly affected hands and feet showing brachydactyly and/or rudimentary fingers (knob-like fingers). AMDM is an autosomal recessive form characterized by axial skeletal involvement with wedging of vertebral bodies. In AMDM all skeletal elements are present but show abnormal rates of linear growth.
Miscellaneous:	There seem to be at least three natriuretic peptide hormone receptors: two with guanylate cyclase activity (NPR1/ANP-A and NPR2/ANP-B) and one (NPR3/ANP-C) which is probably responsible for the clearance of natriuretic peptides from the circulation without a role in signal transduction.
Similarity:	Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
Similarity:	Contains 1 guanylate cyclase domain.
Similarity:	Contains 1 protein kinase domain.

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Menge: 0.02 ml

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