Goat anti Apo AI

Goat

Apolipoprotein AI (Apo AI)

Polyclonal Antibodies to Lipoproteins

20mM Tris pH 7. 4 containing 250mM Sodium chlorideApplications Notes : Specific methodologies have not been tested using this product.

Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT).

Secreted.

Palmitoylated.

Defects in APOA1 are a cause of the low HDL levels observed in high density lipoprotein deficiency type 1 (HDLD1) [MIM:205400]; also known as analphalipoproteinemia or Tangier disease (TGD). HDLD1 is a recessive disorder characterized by the absence of plasma HDL accumulation of cholesteryl esters premature coronary artery disease hepatosplenomegaly recurrent peripheral neuropathy and progressive muscle wasting and weakness. In HDLD1 patients ApoA-I fails to associate with HDL probably because of the faulty conversion of pro-ApoA-I molecules into mature chains either due to a defect in the converting enzyme activity or a specific structural defect in Tangier ApoA-I.

Defects in APOA1 are a cause of amyloidosis type 8 (AMYL8) [MIM:105200]; also known as systemic non-neuropathic amyloidosis or Ostertag-type amyloidosis. AMYL8 is a hereditary generalized amyloidosis due to deposition of apolipoprotein A1 fibrinogen and lysozyme amyloids. Viscera are particularly affected. There is no involvement of the nervous system. Clinical features include renal amyloidosis resulting in nephrotic syndrome arterial hypertension hepatosplenomegaly cholestasis petechial skin rash.