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Rabbit anti Alga PCNA

Rabbit anti Alga PCNA

ArtNr	18-511-245555
Hersteller	GENWAY
Menge	0,1 mg
Kategorie	Oncology Antibodies Western Blot ELISA Primary Antibodies By Organ Bladder Cancer
Typ	Antibody
Applikationen	WB, ELISA
Specific against	other
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-4842E1
Similar products	18-511-245555
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Genway ID:	GWB-4842E1
Host Animal:	Rabbit
Immunogen:	Synthetic peptide corresponding to amino acids 55-71 of Isochrysis galbana PCNA Protein
Sequence:	DRISDFELKLMDIDSEH
Specificity:	Proliferating Cell Nuclear Antigen (PCNA)
Specificity:	Recognizes algal PCNA. BLAST analysis suggests that this antibody would react with PCNA from the following alga sources: Prorocentrum minimum Tetraselmis chui Pleurochrysis carterae and Isochrysis galbana. Species that have been tested but yielded no positive results are Pfiesteria piscicida Emiliania huxleyi Akashiwo sanguinea Rhodomonas sp. Karlodinium micrum and Skletonema costatum. Reactivity with PCNA from other sources has not been determined.
Type of Product:	Polyclonal Antibodies to Proteins and Bioactive Peptides
Concentration:	Lot specific (OD280nm)Preservatives: NaN3
Buffer:	0. 02M Potassium phosphate pH 7. 2 containing 0. 15M Sodium chlorideApplications Notes : Suitable for use in ELISA (1:10 000 ? 1:50 000) and Western blot (1:200 ? 1:2 000). Expect a band at approximately 29 kDa. Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.
Warning:	This product contains sodium azide which has been classified as Xn (Harmful) in European Directive 67/548/EEC in the concentration range of 0. 1â ??1. 0%. When disposing of this reagent through lead or copper plumbing flush with copious volumes of water to prevent azide build-up in drains. Rabbit anti Alga PCNA. Rabbit Antibody to Alga Proliferating Cell Nuclear Antigen (PCNA)
Function:	This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase\' s processibility during elongation of the leading strand.
Subunit:	Homotrimer. Interacts with KCTD10. Interacts with PPP1R15A (By similarity). Forms a complex with activator 1 heteropentamer in the presence of ATP. Interacts with POLH POLK DNMT1 ERCC5/XPG FEN1 CDC6 APEX2 and POLDIP2. Interacts with EXO1 and SHPRH. Forms a ternary complex with DNTTIP2 and core histone. Interacts with POLD1 POLD3 and POLD4.
Subcellular Location:	Nucleus.
Ptm:	Upon methyl methanesulfonate-induced DNA damage mono-ubiquitinated by the UBE2B-RAD18 complex on Lys-164. This induces non-canonical poly-ubiquitination on Lys-164 through \' Lys-63\' linkage of ubiquitin moieties by the E2 complex UBE2N-UBE2V2 and the E3 ligase SHPRH whih is required for DNA repair.
Disease:	Antibodies are present in sera from patients with systemic lupus erythematosus.
Similarity:	Belongs to the PCNA family.

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Menge: 0,1 mg

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