Glutamate receptor 1

GWB-9ED94E

Specific for the ~100k GluR1 protein phosphorylated at Ser845 in Western blots of rat brain extracts. eling is blocked by the phosphopeptide used as the antigen but not by the corresponding dephosphopeptide.

Binds to DLG1.

Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-603 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast Cys-829 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis (By similarity).

Belongs to the glutamate-gated ion channel (TC 1. A. 10) family [view classification]. Summary: mouse homolog may play a role in regulation of neuronal synaptic plasticity and conditioned reinforcement learning [RGD]. [1] von Ossowski L. Tossavainen H. von Ossowski I. Cai C. Aitio O. Fredriksson K. Permi P. Annila A. and Keinanen K. Peptide binding and NMR analysis of the interaction between SAP97 PDZ2 and GluR-A: potential involvement of a disulfide bond[2] Lise M. F. Wong T. P. Trinh A. Hines R. M. Liu L. Kang R. Hines D. J. Lu J. Goldenring J. R. Wang Y. T. and El-Husseini A. Involvement of myosin Vb in glutamate receptor trafficking[3] Oh M. C. Derkach V. A. Guire E. S. and Soderling T. R. et al. Extrasynaptic membrane trafficking regulated by GluR1 serine 845 phosphorylation primes AMPA receptors for long-term potentiation[4] Anborgh P. H. Godin C. Pampillo M. Dhami G. K. Dale L. B. Cregan S. P. Truant R. and Ferguson S. S. Inhibition of metabotropic glutamate receptor signaling by the huntingtin-binding protein optineurin[5] Harms K. J. Tovar K. R. and Craig A. M. et al. Synapse-specific regulation of AMPA receptor subunit composition by activity[6] Hollmann M. O\' Shea-Greenfield A. Rogers S. W. Heinemann S. F. Cloning by functional expression of a member of the glutamate receptor family. [7] Hartley M. Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases. [8] Keinaenen K. Wisden W. Sommer B. Werner P. Herb A. Verdoorn T. A. Sakmann B. Seeburg P. H. A family of AMPA-selective glutamate receptors. [9] Keinanen K. Wisden W. Sommer B. Werner P. Herb A. Verdoorn T. A. Sakmann B. Seeburg P. H. Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases. [10] Boulter J. Hollmann M. O\' Shea-Greenfield A. Hartley M. Deneris E. S. Maron C. Heinemann S. F. Molecular cloning and functional expression of glutamate receptor subunit genes.